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Understanding Sensory and Psychosocial Experiences in Adolescents with Tic Disorder

This observational study aims to better understand the experiences of adolescents (ages 11-17) with tic disorders, including Tourette Syndrome. Researchers want to learn more about how sensory issues (like how you react to sounds or touch), movement difficulties, and overall well-being change over time. There are no interventions or treatments being tested in this study; it's purely about observing and collecting information. By understanding these different symptoms and how they develop, researchers hope to find new ways to improve care and develop better treatments for people with tic disorders. Success for this study means gathering detailed information about these experiences over two years.

Study design
This is an observational study planning to enroll 351 adolescents with tic disorders. It involves tracking their experiences over a two-year period.
What's involved
You would have 4 study visits over 2 years. The first two visits are within 30 days of each other, and the last two are two years later, also within 30 days. Visits involve interviews and questionnaires about your experiences, and some in-person visits include assessments of coordination and other skills.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for two years, with primary endpoints measured from baseline to the 2-year follow-up.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06576726

Sensorimotor and Psychosocial Trajectories in Adolescents With Tic Disorder

Recruiting
Not specifiedAges 11–17Observational
Vanderbilt University Medical Center
~351 participants
Updated 2025-11-24 on ClinicalTrials.gov
What's tested:This study involves no intervention.

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Adolescent/Adult Sensory Profile (AASP)
Measured over from baseline to 2-year follow-up
+8 more outcomes measured

Conditions

Tourette Syndrome
Tic Disorder

Explore related trials

Tic disorderTourette Syndrome

Where it's being run

1 sites across 1 states
Tennessee1

Study leadership

  • David Isaacs, MD, MPH · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center

Who to contact

Michelle Clinical Translational Research Coordinator II
[email protected]
615-875-7394
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

adolescent age 11-17 years of age
adolescent diagnosis of chronic tic disorder (Tourette syndrome, chronic motor tic disorder, chronic vocal tic disorder)
English-speaking adolescent and caregiver/adult proxy (as validated questionnaires are in English)
adolescent and caregiver/adult proxy willingness and ability to complete relevant questionnaires
adolescent age 11-17 years of age
English-speaking adolescent and caregiver/adult proxy (as validated questionnaires are in English)
adolescent and caregiver/adult proxy willingness and ability to complete relevant questionnaires

Exclusion

cognitive or attentional impairment precluding ability of adolescent or caregiver/adult proxy to complete questionnaires and other study measures
adolescent diagnosis of autism spectrum disorder (ASD) or psychotic disorder
adolescent diagnosis of pervasive genetic disorder besides chronic tic disorders and their known comorbidities
adolescent with severe medical conditions unrelated to chronic tic disorders (e.g. uncontrolled seizures, prominent heart conditions)
other variables that might influence ratings outside of the typical presentation of chronic tic disorders
adolescent treatment with stimulant medications or anti-seizure medications within the past 30 days
use of marijuana or recreational substances within the past 30 days
history of seizure
history of hearing loss or abnormalities
history of neuropathy or overt sensory deficit
history of brain surgery or skull-penetrating/deforming trauma
history of stroke, brain cancer, or other significant neurologic illness/disorder \*\* Individuals excluded based on these criteria are ineligible for the EEG portion of the study but can complete the remainder of the study measures.
history of tics, ADHD, OCD, or other significant neurodevelopmental or neuropsychiatric disorder.
cognitive or attentional impairment precluding ability of adolescent or caregiver/adult proxy to complete questionnaires and other study measures
adolescent diagnosis of autism spectrum disorder (ASD) or psychotic disorder
adolescent diagnosis of pervasive genetic disorder
adolescent with severe medical conditions (e.g. uncontrolled seizures, prominent heart conditions)
other variables that might influence ratings
adolescent treatment with stimulant medications or anti-seizure medications within the past 30 days
use of marijuana or recreational substances within the past 30 days
history of seizure
history of hearing loss or abnormalities
history of neuropathy or overt sensory deficit
history of brain surgery or skull-penetrating/deforming trauma
history of stroke, brain cancer, or other significant neurologic illness/disorder

What this trial measures

  • Adolescent/Adult Sensory Profile (AASP)from baseline to 2-year follow-up

    validated, 60-item self-report questionnaire assessing sensory experiences

  • Sensory Perception Quotientfrom baseline to 2-year follow-up

    35-item self-report questionnaire assessing self-perceived basic sensory sensitivity

  • Sensory Gating Inventoryfrom baseline to 2-year follow-up

    validated, 36-item self-report questionnaire assessing sensory over-responsivity

  • Adolescent Motor Competence Questionnaire (AMCQ)from baseline to 2-year follow-up

    validated, 26-item self-report questionnaire assessing self-perceived coordination

  • Bruininks-Oseretsky Test of Motor Proficiency, 2nd edition (BOT-2)from baseline to 2-year follow-up

    validated, rater-administered scale assessing motor coordination

  • Purdue pegboardfrom baseline to 2-year follow-up

    validated, rater-administered task assessing manual dexterity and coordination

  • Vibrotactile battery, with BrainGauge (CM4)from baseline to 2-year follow-up

    Device- and rater-administered battery assessing several features of vibrotactile threshold perception, including static threshold detection, dynamic threshold detection, amplitude discrimination without and with adaptation, sequential and simultaneous frequency discrimination

  • Tactile gating indicesfrom baseline to 2-year follow-up

    Participants will undergo a tactile gating paradigm, while monitored on electroencephalogram (EEG), during which puffs of air will be administered to the index finger.

  • Contingent negative variation indicesfrom baseline to 2-year follow-up

    Participants will undergo a contingent negative variation paradigm, while monitored on electroencephalogram (EEG), during which puffs of air will be administered to the index finger, cueing the participant to respond