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NCT06578117

Statistical Learning as a Novel Intervention for Cortical Blindness

Enrolling by Invitation
NAAges 21–75InterventionalBasic science
University of Rochester
~30 participants
Updated 2026-01-30 on ClinicalTrials.gov
What's tested:Vision Training and Learning Task

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Explicit Learning - Response Time
Measured over Baseline
+1 more outcome measured

Conditions

Stroke, Ischemic
Hemianopia, Homonymous
Hemianopsia
Occipital Lobe Infarct
Visual Field Defect, Peripheral
Vision Loss Partial
Quadrantanopia
Stroke Hemorrhagic

Explore related trials

Cortical BlindnessHomonymous hemianopiaStrokeVisual Field Defect

Where it's being run

1 sites across 1 states
New York1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Between 21 and 75 years of age
Residents of the United States or Canada
Have successfully completed previous enrollment in Dr. Huxlin study (IRB #5966 or #75)
Exhibit unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 75 years (verified by MRI and/or CT scans)
Reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey visual fields. This deficit must be large enough to enclose a 5-deg diameter visual stimulus.
Able to fixate on visual targets reliably for 1000ms within 1-deg of visual angle.
Willing, able, and competent to provide their own informed consent
Normal cognitive abilities and be able to understand written and oral instructions in English
Between 21 and 75 years of age
No history of neurological disorder.
Competent and responsible, as determined by the screening interview

Exclusion

Past or present ocular disease interfering with visual acuity
Best corrected visual acuity (BCVA) worse than 20/40 in either eye
Sustained documented or suspected damage to the dorsal Lateral Geniculate Nucleus
Presence of diffuse whole brain degenerative processes
History of traumatic brain injury
Any other brain damage deemed by study staff to potentially interfere with training ability or outcome measures
Documented history of drug/alcohol abuse
Currently taking neuroactive medications which would impact training, as determined by PI
Cognitive or seizure disorders
One-sided attentional neglect
Those who lack the competence or are otherwise unable to perform the visual training exercises as directed.
Any damage to the visual system
Those who are suffering from an active disease process involving their nervous system.
Presence of cognitive or seizure disorders
Best corrected visual acuity worse than 20/40 in either eye
Presence of visual field loss from ocular disease or disorder

What this trial measures

  • Explicit Learning - Response TimeBaseline

    Reaction time (ms) when performing motion discriminations for the final stimulus of a statistically-linked triplet will be compared against reaction times for stimuli with identical motion directions, presented with alternative placement within a triplet. Comparisons will be made only for correct responses in the final 20% of overall testing session trials.

  • Implicit Learning - Triplet FamiliarityBaseline

    Participant familiarity with statistically-linked triplets of motion will be assessed via a two-interval, forced-choice task. Familiarity will be measured as a percentage of comparisons in which the more prevalent triplet is selected as more familiar. Familiarity of high-probability, low-probability, and null-probability triplets will be compared following training.