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Nasal High Flow for Exercise Tolerance in COPD

This study is looking at how using a Nasal High Flow Cannula (a device that provides warm, moist air at a high flow rate) affects people with Chronic Obstructive Pulmonary Disease (COPD) during exercise. Researchers want to see if it helps you walk further in a 6-minute walk test and how it impacts your shortness of breath (dyspnea). You might be able to join if you are 18 or older, have COPD, can walk without help, and use little to no supplemental oxygen. The study aims to enroll 45 participants.

Study design
This interventional study plans to enroll 45 participants to compare the effects of Nasal High Flow Cannula and Nasal Low Flow Cannula.
What's involved
You would participate in person, potentially up to 6 times, depending on your availability. The main test involves a 6-minute walk test.
Compensation
Not stated in the trial record.
Follow-up
The primary outcome, the 6-minute walk test, is measured at 30 minutes after the intervention.

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NCT06578156

Physiologic Effects of Nasal High Flow on Exercise Tolerance in COPD

Recruiting
NAAges 18+InterventionalTreatment
University of Miami
~45 participants
Updated 2026-06-22 on ClinicalTrials.gov
What's tested:Nasal High Flow CannulaNasal Low Flow Cannula

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
6-minute walk test
Measured over 30 minutes

Conditions

COPD

Explore related trials

Chronic Obstructive Pulmonary Disease

Where it's being run

1 sites across 1 states
Florida1

Study leadership

  • Saramaria Afanador Castiblanco, M.D. · PRINCIPAL_INVESTIGATOR · University of Miami

Who to contact

Saramaria Afanador Castiblanco, M.D.
[email protected]
305-243-2568
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Able to consent
Age 18 years or older
Diagnosis of COPD
Ability to ambulate without assistance
Use of low-flow nasal cannula ≤ 4 L/min or no supplemental oxygen (O2) at all

Exclusion

Pregnancy
Being on bedrest
Inability to consent or cooperate with the study
Using of \> 4 L/min of supplemental O2 or requiring non-invasive ventilation during the daytime
Hemodynamic instability (resting heart rate \> 130/minute, systolic blood pressure of ≤ 90 mmHg or ≥ 180 mmHg)
Metal implants in the thoracic regions (pacemakers, Automatic Implantable Cardioverter Defibrillator (AICD), plates, screws, rods, and disc replacements)

What this trial measures

  • 6-minute walk test30 minutes

    The object of the test is to walk as far as possible for six minutes. The subject will walk at a normal pace around a marked course for six minutes. The distance walked in meters over 6 minutes will be measured.