ART-Pro: Advanced MRI for Prostate Cancer Detection

This study, called ART-Pro, is looking at new ways to use MRI (magnetic resonance imaging) to find prostate cancer that needs treatment. It's comparing standard MRI (mpMRI) with two newer techniques: biparametric MRI (bpMRI) and Restriction Spectrum Imaging (RSIrs). The goal is to see if these newer methods can help doctors who aren't prostate MRI experts find important cancers as well as experts can, and without needing an IV (intravenous) contrast injection. You might be able to join if you are a man aged 18 or older, have been referred for a prostate MRI because your doctor suspects prostate cancer, and your MRI can follow a specific procedure. The study will measure how many patients are diagnosed with a significant prostate cancer (grade group ≥2) after 6 months. The current recruitment status is unclear.

Study design
This is an observational study planning to enroll 500 participants across 5 centers. It will compare different MRI techniques for detecting prostate cancer.
What's involved
You will have an MRI scan using a specific protocol. Your medical outcomes, like biopsy results or surgery information, will be collected after you join.
Compensation
Not stated in the trial record.
Follow-up
Patients will be followed after initial enrollment to collect medical outcomes, such as biopsy results or surgery pathology, with the primary endpoint measured at 6 months.

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NCT06579417

ART-Pro: Clinical Trial Evaluating Biparametric MRI and Advanced, Quantitative Diffusion MRI for Detection of Prostate Cancer

Recruiting
Not specifiedAges 18+Observational
University of California, San Diego
~500 participants
Updated 2024-11-06 on ClinicalTrials.gov
What's tested:RSI MRI

At a glance

Recruiting sites
1 of 5 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Proportion of patients diagnosed with a grade group ≥2 prostate cancer on biopsy
Measured over 6 months
Prostate Cancer
5 sites across 4 states
California2
Massachusetts1
New York1
Cambridgeshire1
  • Tyler Seibert, MD, PhD · PRINCIPAL_INVESTIGATOR · University of California, San Diego

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Eligibility criteria

Inclusion

18 years of age or older
Referred for mpMRI of the prostate for suspicion of prostate cancer
MRI is conducted using the standardized ART-Pro acquisition protocol

Exclusion

Currently incarcerated
Previous diagnosis of prostate cancer
Active non-prostate tumor(s) in structures of the body near the prostate
Previous prostate surgery
History of hip implant
Metal implants or implanted devices in the body or other criteria that are deemed to require deviation from the usual acquisition protocol or scanning procedures
  • Proportion of patients diagnosed with a grade group ≥2 prostate cancer on biopsy6 months