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NCT06580041

Precision Care for Major Depressive Disorder

Enrolling by Invitation
PHASE4Ages 18+InterventionalTreatment
University of California, San Francisco
~150 participants
Updated 2025-09-05 on ClinicalTrials.gov
What's tested:PramipexoleMethylphenidatePhenelzineMindfulness-based Stress Sensitivity Therapy (MBSST)Complicated Grief Treatment (CGT)Care as usual (CAU) plan

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Quick Inventory of Depressive Symptoms - Self-Report 16-Item (QIDS-SR-16) score
Measured over Up to 24 weeks after randomization.

Conditions

Major Depressive Disorder
Depression
Depressive Disorder, Major

Explore related trials

Unipolar Depression

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Andrew D. Krystal, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Participant is able to provide informed consent
English speaker
18 years of age or older at time of consent
Meets DSM-5 criteria for Major Depressive Disorder
The subject meets eligibility criteria for at least one study phenotype as determined by assessments, imaging and/or clinical judgment.
PHQ-8 score at baseline of \>= 10
Scheduled for or completed intake in UCSF outpatient psychiatry

Exclusion

Unstable or untreated medical or psychiatric condition based on clinical assessment by investigator(s)
Significant risk of suicidal or violent behavior as determined by clinical judgement
In the Investigators' opinion, the subject is not capable of adhering to the protocol requirements, or the subject has a history of poor or suspected poor compliance in clinical research studies, or the subject has a history of poor or suspected poor compliance to antidepressant medication or that study participation is not in their best interest (e.g., different treatment is indicated given their clinical presentation)
Pregnant or breastfeeding or planning to become pregnant during the study

What this trial measures

  • Quick Inventory of Depressive Symptoms - Self-Report 16-Item (QIDS-SR-16) scoreUp to 24 weeks after randomization.

    Within-phenotype and across-phenotype contrasts.