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Aging, Beta Blockers, and Heat Responses

This study is looking at how two common medications, propranolol and metoprolol (types of beta blockers), affect older adults when they are exposed to extreme heat. Researchers want to see if these drugs cause a greater increase in core body temperature (your internal temperature) during a 3-hour heat exposure. You might be able to join if you are 65 or older, healthy, have normal heart readings, and your cholesterol and blood pressure are controlled. The main goal is to measure your internal temperature continuously and your sweat rate before and after the heat exposure. The current status of this study is unclear, and it plans to enroll 22 participants.

Study design
This is an interventional study planning to enroll 22 participants. It is not specified if it is randomized or blinded.
What's involved
You would spend 3 hours in a heat chamber at 41°C (105.8°F) and 40% humidity. Your nude body mass will be measured before and after this exposure.
Compensation
Not stated in the trial record.
Follow-up
Your internal temperature will be measured continuously throughout the 3-hour heat exposure, and your sweat rate will be measured before and after this period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06582680

Aging, Beta Blockers, and Thermoregulatory Responses

Recruiting
PHASE4Ages 65+InterventionalBasic science
University of Texas Southwestern Medical Center
~22 participants
Updated 2025-10-23 on ClinicalTrials.gov
What's tested:Ambient Heat

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Internal temperature
Measured over Continuously throughout the 3-hour heat exposure.
+1 more outcome measured

Conditions

Heat Stress
Aging

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NCT06582680

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • IEEM Texas Health Presbyterian Hospital Dallas

    Dallas, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Craig Crandall, PhD · PRINCIPAL_INVESTIGATOR · Univ of Texas Southwestern Med Ctr

Who to contact

Erin Harper, MS
[email protected]
214-345-4737
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Healthy and free of any significant medical problems
Normal resting electrocardiogram
65+ years of age
Controlled cholesterol of less than 200 mg/dl
Controlled blood pressure of less than 140/90 mmHg

Exclusion

Known diseases or other chronic conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia
Serious abnormalities detected on routine screening
Taking prescribed medications or over-the-counter medications that have known influences on either cardiac function or sweating
Current smokers, as well as individuals who regularly smoked within the past 3 years
body mass index ≥31 kg/m2

What this trial measures

  • Internal temperatureContinuously throughout the 3-hour heat exposure.

    The change in internal temperature to the 3-hour heat exposure will be measured.

  • Whole body sweat rateNude body mass will be measured before and after the 3-hour heat exposure.

    Whole body sweat rate will be measured via changes in pre/post nude body mass.