Study of Cemiplimab for Early-Stage Cutaneous Squamous Cell Carcinoma

This study is investigating cemiplimab, a medication that helps your immune system fight cancer, for adults with early-stage cutaneous squamous cell carcinoma (CSCC), a type of skin cancer. Cemiplimab works by targeting a protein called PD-1. The study aims to see how well cemiplimab, when injected directly into the tumor, compares to standard surgery. Researchers will also look at any side effects. You may be eligible if you are an adult with a CSCC tumor between 1 cm and 2 cm on your head, neck, hand, or lower leg. The study plans to enroll 369 participants, but its current status is unclear.

Study design
This interventional study plans to enroll 369 participants. It compares cemiplimab injections to standard surgery.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for Event-Free Survival for up to 3 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06585410

Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

Recruiting
PHASE3Ages 18+InterventionalTreatment
Regeneron Pharmaceuticals
~369 participants
Updated 2026-08-17 on ClinicalTrials.gov
What's tested:CemiplimabStandard of care

At a glance

Recruiting sites
49 of 52 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Event-Free Survival (EFS) as assessed by the investigator
Measured over Up to 1 year
+1 more outcome measured
Cutaneous Squamous Cell Carcinoma (CSCC)
52 sites across 30 states
Texas6
California4
Arizona3
Florida3
New York3
Illinois2
Massachusetts2
Michigan2
  • Clinical Trial Management · STUDY_DIRECTOR · Regeneron Pharmaceuticals

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  • Event-Free Survival (EFS) as assessed by the investigatorUp to 1 year
  • EFS as assessed by the investigatorUp to 3 years