Strength Training and Resveratrol for Sarcopenia and Anabolic Resistance
This study is investigating whether taking resveratrol (a dietary supplement) can improve how muscles respond to strength training in adults aged 60 and older who are experiencing sarcopenia (age-related muscle loss) and anabolic resistance (difficulty building muscle). Participants will be randomly assigned to receive either 500 mg of resveratrol or a placebo (an inactive capsule) daily. Everyone in the study will also do supervised, full-body strength training three times a week for 12 weeks. Researchers will measure changes in muscle strength, muscle fatigue, and certain markers in the blood to see if resveratrol helps. The study aims to enroll 36 participants. The current status of the study is unclear.
- Study design
- This is an interventional study with 36 planned participants. It is a double-blinded study, meaning neither you nor the study team will know if you are receiving resveratrol or the placebo.
- What's involved
- You would undergo pre-testing, then take a daily capsule and participate in supervised strength training three times a week for two 6-week blocks. There will also be testing weeks after each block.
- Compensation
- Not stated in the trial record.
- Follow-up
- Muscle torque and fatigability will be measured during pre-, mid-, and post-testing, with each testing period separated by about 6 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Strength Training and Resveratrol
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Danielle E Levitt, PhD · PRINCIPAL_INVESTIGATOR · Texas Tech University
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Inclusion
Exclusion
What this trial measures
- Circulating extracellular vesicle microRNA profileDuring pre-, mid-, and post-testing (each separated by about 6 weeks)
Circulating extracellular vesicles will be isolated from plasma and their microRNA cargo will be sequenced.
- Muscle torqueDuring pre-, mid-, and post-testing (each separated by about 6 weeks)
Participants will be instructed to try and straighten their leg, against resistance, as forcefully as possible and maximal torque of the quadriceps assessed using a dynamometer.
- Muscle fatigabilityDuring pre-, mid-, and post-testing (each separated by about 6 weeks)
Participants will perform 32 repetitions of knee extensions on a dynamometer and the change in torque from the beginning to the end will be used to indicate fatigability.
- Muscle strengthDuring pre-, mid-, and post-testing (each separated by about 6 weeks)
Participants will perform submaximal testing to assess strength on key exercises included in the strength training protocol.
- Appendicular skeletal muscle mass indexDuring pre-, mid-, and post-testing (each separated by about 6 weeks)
Assessed using dual-energy x-ray absorptiometry (DEXA)