Targeted Cognitive Training for Veterans with Serious Mental Illness
This study is for Veterans with serious mental illnesses (SMI) like schizophrenia, psychosis, PTSD, or schizoaffective disorder. It's testing an intervention called Targeted Cognitive Training (TCT), which is a computer-based program designed to improve how your brain processes sounds. The goal is to see if TCT can help improve your clinical symptoms, thinking abilities (cognition), and daily functioning. Researchers will measure these improvements after 22 weeks. You may be able to join if you are a Veteran between 18 and 83 years old, fluent in English, and can hear certain sounds. The study aims to enroll 80 participants, but its current status is unclear.
- Study design
- This is an interventional study planning to enroll 80 participants. It is testing a behavioral intervention called Targeted Cognitive Training (TCT).
- What's involved
- Participants will engage in Targeted Cognitive Training (TCT), a computer-based program. Your clinical symptoms, cognition, and functional abilities will be measured after 22 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be assessed for clinical symptoms, cognition, and function at 22 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Enhancing Rehabilitation for Veterans With Serious Mental Illness
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Gregory Light, PhD · PRINCIPAL_INVESTIGATOR · VA San Diego Healthcare System, San Diego, CA
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Clinical Symptoms - Positive and Negative Syndrome Scale (PANSS)22 weeks
Change from baseline clinical symptoms Positive and Negative Syndrome Scale (PANSS) The Positive and Negative Syndrome Scale (PANSS) will used to evaluate the presence, absence and severity of Positive, Negative and General Psychopathology symptoms of SZ. The PANSS is a 30-item scale arranged as 7 positive symptom subscale items, 7 negative symptom subscale items, and 16 general psychopathology symptom items. Each item has a definition and a basis for rating. All 30 items are rated on a 7-point scale (1=absent; 7=extreme). On the PANSS lower values are considered to be a better outcome.
- Cognition - Matrics Consensus Cognitive Battery (MCCB)22 weeks
Change from baseline cognition Matrics Consensus Cognitive Battery (MCCB) performance Change in Matrics Consensus Cognitive Battery (MCCB) performance from baseline is the outcome measure for cognition (using age- and gender-corrected T scores). The MCCB measures 7 cognitive domains: speed of processing, attention/vigilance, working memory (verbal and nonverbal), verbal learning, visual learning, reasoning/ problem solving and social cognition. MCCB verbal learning T-score is the primary cognitive outcome measure. Other MCCB domain T- scores will be used in secondary analyses. On the MCCB higher scores are indicative of better outcome.
- Function - Functional Capacity: UCSD Performance-Based Skills Assessment, Brief Version (UPSA-B)22 weeks
Functional Capacity will be assessed with the UCSD Performance-Based Skills Assessment, Brief Version (UPSA-B) at study entry and assessment intervals. The UPSA takes \~15 min to complete and incorporates role play to assess functional capacity in four broad domains: planning recreational activities, finances, communication and transportation. Raw scores on each subtest are transformed into a standardized subscale scores (0-25), which are summated to an overall
- Function - Psychosocial Recovery: World Health Organization Disability Schedule 2.0 (WHODAS)22 weeks
World Health Organization Disability Schedule 2.0 (WHODAS) will be used to assess psychosocial recovery. This detailed assessment consists of a 36-item questionnaire, where patients rate various aspects on a 5-point Likert scale. It covers six critical domains: cognition, mobility, self-care, social interactions, life activities, and societal participation. The WHODAS 2.0 will be used as an outcome measure for psychosocial recovery. Lower scores indicate better outcome on the WHODAS 2.0.