Noninvasive Vagal Nerve Stimulation for Traumatic Brain Injury

This study is looking at whether a device called transcutaneous auricular vagus nerve stimulation (tVNS) can help improve thinking skills in people recovering from a mild to moderate traumatic brain injury (TBI). tVNS uses a device placed on the ear to stimulate a nerve. Researchers want to see if this stimulation, when combined with tasks that challenge your thinking, can help you recover better. You might be able to join if you are 18-65 years old, are currently in inpatient rehabilitation for a recent TBI, can use a keyboard, speak English, and can give your own consent. The study will measure success by looking at how well participants perform on computer tasks and a test called the Trail Making Test. The study is currently recruiting about 60 participants.

Study design
This is an interventional study involving about 60 participants. It compares active tVNS with a sham (inactive) stimulation, with the order of these treatments being varied among participants.
What's involved
You would participate in two sessions, 2-7 days apart. In each session, you would receive either active or sham stimulation while performing thinking tasks.
Compensation
Not stated in the trial record.
Follow-up
Your performance on tasks will be measured at 5 and 15 minutes during the study sessions.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06589362

Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation

Recruiting
NAAges 18–65InterventionalTreatment
Shirley Ryan AbilityLab
~60 participants
Updated 2025-03-25 on ClinicalTrials.gov
What's tested:Transcutaneous auricular vagus active nerve stimulationTranscutaneous auricular vagus sham nerve stimulation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
N-Back Computerized Task
Measured over 15 minutes
+1 more outcome measured
Traumatic Brain Injury
1 sites across 1 states
Illinois1
  • Shira Cohen-Zimerman, PhD · PRINCIPAL_INVESTIGATOR · Shirley Ryan AbilityLab

Opens a ready-to-send draft in your own email app — review before sending.

  • N-Back Computerized Task15 minutes

    In the n-back task, participants are presented a series of visual stimuli. They are asked for each stimulus whether it matches a stimulus n trials before. For example, in a 2-back task, in which the trials consist of letters, participants have to decide whether the current letter is the same as the letter in trial n - 2. We will use a computerized version of this task.

  • Trail Making Test - Parts A & B5 minutes

    Trail Making Part A requires participants to draw a line between circles containing numbers in ascending order (e.g., 1-2- 3...etc.). Part B requires participants to alternate drawing a line between ascending letters and numbers (e.g., 1-A-2-B...etc.). The key measures are the time required to complete and the number of errors made in Part A and Part B. This test measures various aspects of cognition including attention, visual search, motor coordination, reasoning, and task-switching.