Noninvasive Vagal Nerve Stimulation for Traumatic Brain Injury
This study is looking at whether a device called transcutaneous auricular vagus nerve stimulation (tVNS) can help improve thinking skills in people recovering from a mild to moderate traumatic brain injury (TBI). tVNS uses a device placed on the ear to stimulate a nerve. Researchers want to see if this stimulation, when combined with tasks that challenge your thinking, can help you recover better. You might be able to join if you are 18-65 years old, are currently in inpatient rehabilitation for a recent TBI, can use a keyboard, speak English, and can give your own consent. The study will measure success by looking at how well participants perform on computer tasks and a test called the Trail Making Test. The study is currently recruiting about 60 participants.
- Study design
- This is an interventional study involving about 60 participants. It compares active tVNS with a sham (inactive) stimulation, with the order of these treatments being varied among participants.
- What's involved
- You would participate in two sessions, 2-7 days apart. In each session, you would receive either active or sham stimulation while performing thinking tasks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your performance on tasks will be measured at 5 and 15 minutes during the study sessions.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Noninvasive Vagal Nerve Stimulation and Cognitive Rehabilitation
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Shira Cohen-Zimerman, PhD · PRINCIPAL_INVESTIGATOR · Shirley Ryan AbilityLab
Who to contact
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What this trial measures
- N-Back Computerized Task15 minutes
In the n-back task, participants are presented a series of visual stimuli. They are asked for each stimulus whether it matches a stimulus n trials before. For example, in a 2-back task, in which the trials consist of letters, participants have to decide whether the current letter is the same as the letter in trial n - 2. We will use a computerized version of this task.
- Trail Making Test - Parts A & B5 minutes
Trail Making Part A requires participants to draw a line between circles containing numbers in ascending order (e.g., 1-2- 3...etc.). Part B requires participants to alternate drawing a line between ascending letters and numbers (e.g., 1-A-2-B...etc.). The key measures are the time required to complete and the number of errors made in Part A and Part B. This test measures various aspects of cognition including attention, visual search, motor coordination, reasoning, and task-switching.