Endoscopic Ultrasound Shear Wave Elastography Study for Liver Disease

This study is looking at new ways to check for liver scarring (fibrosis) in people with liver conditions like MASLD and MASH. It's testing a device called Endoscopic Ultrasound Shear Wave Elastography (EUS) and Attenuation Imaging. EUS uses a special ultrasound camera that goes inside your body to get very clear pictures of your liver and measure its stiffness. Researchers want to see how well these EUS measurements compare to results from a liver biopsy (taking a small sample of liver tissue) and another test called FibroScan, which also measures liver stiffness. You might be able to join if you are 18 or older, are scheduled for an EUS with a liver biopsy, and are willing to give your consent. The study will consider EUS successful if its measurements of liver stiffness match up well with the results from a liver biopsy.

Study design
This is an observational study involving up to 300 participants at multiple sites. It is a single-arm study, meaning all participants will receive the same set of evaluations.
What's involved
You would undergo an Endoscopic Ultrasound with Shear Wave Elastography and Attenuation Imaging, a liver biopsy, and a FibroScan. The liver biopsy and FibroScan should be done within three months of the EUS.
Compensation
Not stated in the trial record.
Follow-up
Your participation in the study will end once your liver biopsy pathology results have been obtained.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06592820

Endoscopic Ultrasound Shear Wave Elastography Study

Recruiting
Not specifiedAges 18+Observational
Olympus Corporation of the Americas
~300 participants
Updated 2025-09-15 on ClinicalTrials.gov
What's tested:Endoscopic Ultrasound Shear Wave Elastography (EUS) and Attenuation ImagingFibroScanLiver biopsy

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Shear Wave Elastography (SWE) vs liver biopsy METAVIR staging system
Measured over During study data analysis
MASLD
MASH
Fibrosis, Liver
Chronic Liver Disease
2 sites across 2 states
Massachusetts1
Pennsylvania1
  • Marvin Ryou, MD · PRINCIPAL_INVESTIGATOR · Brigham and Women's Hospital, Boston, MA

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  • Shear Wave Elastography (SWE) vs liver biopsy METAVIR staging systemDuring study data analysis

    Establish optimal cutoffs for EUS-SWE cutoffs in reference to liver biopsies on METAVIR staging system for significant fibrosis (F0-1 vs F2-4), advanced fibrosis (F0-2 vs F3-4), and cirrhosis (F0-3 vs F4) based on area under the receiver operator characteristics (AUROC) curve analysis.