STRONG-DM Study: Heart Failure Prevention in Type 2 Diabetes

This study, called STRONG-DM, is looking at a new way to prevent heart failure in people with type 2 diabetes. It's testing an "Intensive Prevention Strategy" where your primary care doctor would get alerts if you have a high risk of heart failure. These alerts would recommend specific treatments like SGLT2 inhibitors, GLP1 agonists, or non-steroidal MRAs, or suggest a referral to a heart health program. The study wants to see if this strategy can reduce new cases of heart failure or death from any cause over two years. This study is for primary care providers who see patients with diabetes.

Study design
This is a pragmatic, randomized clinical trial with a planned enrollment of 300 participants. Primary care providers will be randomly assigned to receive notifications about high-risk patients.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for two years to track incident heart failure or all-cause death.

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NCT06593327

NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study

Recruiting
NAAll AgesInterventionalPrevention
University of Texas Southwestern Medical Center
~300 participants
Updated 2026-02-27 on ClinicalTrials.gov
What's tested:Intensive Prevention Strategy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incident Heart Failure or All-cause death
Measured over 2-year follow-up
Type 2 Diabetes
Diabetic Cardiomyopathy
Heart Failure
Cardiometabolic Diseases
1 sites across 1 states
Texas1

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Eligibility criteria

Inclusion

Primary Care Provider that sees diabetes patients in clinic

Exclusion

Provider does not see patients with Diabetes
  • Incident Heart Failure or All-cause death2-year follow-up

    Incident Heart Failure (based on electronic health record International Classification of Diseases codes) or all-cause death. This will be assessed via retrospective chart review.