Eating Disorders Genetics Initiative 2 (EDGI2)

The Eating Disorders Genetics Initiative 2 (EDGI2) is an observational study aiming to understand eating disorders better. Researchers are looking for 20,000 participants aged 12 to 99 with a lifetime history of anorexia nervosa, bulimia nervosa, binge-eating disorder, or avoidant restrictive food intake disorder, as well as people with no history of disordered eating. This study does not involve any active treatment. Instead, it focuses on identifying participants with different eating disorder diagnoses and their age of onset. The goal is to gather more diverse information to help develop better treatments in the future.

Study design
This is an observational study with a planned enrollment of 20,000 participants. You will be assigned to an eating disorder diagnosis group based on your lifetime history.
What's involved
You will be asked to complete a series of questionnaires and provide a saliva sample for genetic testing.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

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NCT06594913

Eating Disorders Genetics Initiative 2

Recruiting
Not specifiedAges 12–99Observational
University of North Carolina, Chapel Hill
~20,000 participants
Updated 2026-07-08 on ClinicalTrials.gov
What's tested:Eating disorder diagnosis group

At a glance

Recruiting sites
5 of 5 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of Participants Identified with an Eating Disorder Diagnosis by Category
Measured over Baseline
+1 more outcome measured
Anorexia Nervosa
Bulimia Nervosa
Binge-Eating Disorder
Avoidant Restrictive Food Intake Disorder
5 sites across 5 states
North Carolina1
Queensland1
Mexico1
Canterbury1
Sweden1
  • Cynthia Bulik, PhD · PRINCIPAL_INVESTIGATOR · University of North Carolina, Chapel Hill

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Eligibility criteria

Inclusion

A lifetime history of anorexia nervosa, bulimia nervosa, binge-eating disorder, avoidant restrictive food intake disorders or no history of any disordered eating behavior, based on DSM-5 criteria algorithms
Age 12-99 years, depending on country. (US enrollment age is 18-99)

Exclusion

History of subthreshold disordered eating behaviors.
  • Number of Participants Identified with an Eating Disorder Diagnosis by CategoryBaseline

    The ED100Kv4 is a web-based diagnostic questionnaire, based on the Structured Clinical Interview for Axis 1 Disorders, that applies algorithms to participant responses. The number of participants with each diagnosis (AN, BN, BED, ARFID, and control) will be reported.

  • Age of eating disorder onsetBaseline

    Age of eating disorder onset will be considered as the age of first eating disorder symptom as self-reported in the ED100Kv4 questionnaire (ED100K). Age of onset will be reported for each eating disorder group.