This study is looking into aortic stenosis, a common heart valve disease where the valve narrows, making it harder for your heart to pump blood. This condition is more common in men. Researchers want to see if there's a connection between aortic stenosis and the loss of the Y chromosome (a male-specific chromosome) in circulating blood cells. They will do this by analyzing your blood for the percentage of circulating leukocytes (a type of white blood cell) that have lost the Y chromosome. The study is open to men aged 40 and older who have aortic stenosis (valve area less than 1.5cm2). You cannot join if you have a bicuspid aortic valve, a history of chest radiation, certain inflammatory diseases, or active cancer. The goal is to understand if this loss of the Y chromosome is linked to the development of aortic stenosis.

Study design

This is an observational study, meaning researchers will observe and collect information without giving any new treatments. They plan to include 200 male participants.

What's involved

You would provide a blood sample for analysis of the Y chromosome. This measurement will be taken at one day.

Compensation

Not stated in the trial record.

Follow-up

Your Y chromosome levels will be measured at one day, which is the primary endpoint for this study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.