The Options 2 Study: Nicotine Pouches and Lozenges for Smokers

The Options 2 Study is looking at how well nicotine pouches and mini nicotine lozenges can replace cigarettes for people who smoke. Researchers want to see if these products can help you switch from smoking. You might be able to join if you are at least 21 years old, smoke 5 or more cigarettes a day, and are not planning to quit smoking in the next 30 days. The main goal is to measure how many cigarettes you smoke each day during a 21-day period while using one of the study products or no product. The study is currently recruiting 300 participants, but its overall status is unclear.

Study design
This is an interventional study with 300 planned participants. It is a randomized controlled trial with four groups.
What's involved
You will have 6 in-person research visits and 1 follow-up call. You will also complete questionnaires and use a smartphone app to track your smoking and product use.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured from baseline to 3 weeks.

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NCT06595459

The Options 2 Study

Recruiting
PHASE4Ages 21+InterventionalTreatment
University of Wisconsin, Madison
~300 participants
Updated 2026-06-22 on ClinicalTrials.gov
What's tested:Nicotine PouchesMini Nicotine lozenges

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mean number of cigarettes smoked per day during the 21-day switching period.
Measured over Baseline to 3 weeks
Smoker
Smoking Cessation
1 sites across 1 states
Wisconsin1
  • Megan Piper, PhD · PRINCIPAL_INVESTIGATOR · University of Wisconsin, Madison

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

≥ 21 years old (i.e., able to legally purchase tobacco products)
able to read and communicate in English
no plans to quit smoking in the next 30 days
willing to stop using nicotine replacement or varenicline
willing to stop using bupropion (i.e., Wellbutrin, Zyban) if they are currently using it only for smoking cessation
smoking ≥ 5 cigarettes per day for the past 6 months
exhaled carbon monoxide ≥ 6 ppm
no nicotine pouch or smokeless tobacco (including snus) use within the last 6 months

Exclusion

currently in treatment for psychosis or bipolar disorder
currently taking bupropion for non-smoking cessation reasons (e.g., Wellbutrin for depression)
currently pregnant or breastfeeding
  • Mean number of cigarettes smoked per day during the 21-day switching period.Baseline to 3 weeks

    Participants will self-report on their cigarette use