Neurophysiological Investigation of Deep Brain Stimulation for OCD
This study is looking at how Deep Brain Stimulation (DBS) works in people with severe Obsessive-Compulsive Disorder (OCD) who haven't improved with other treatments. Researchers will implant a device called DBS SenSight leads and a Medtronic Percept RC IPG, which can record brain activity. They want to understand how brain activity changes with DBS and how this relates to OCD symptoms. You might be able to join if you are 22-64 years old, have had OCD for at least five years that hasn't responded to multiple medications like SSRIs and clomipramine, and meet other specific criteria. The main goal is to see if your OCD symptoms improve after 14 months.
- Study design
- This interventional study plans to enroll 10 participants. It is not specified if it's randomized or blinded.
- What's involved
- You would undergo surgical implantation of DBS SenSight leads and a Medtronic Percept RC IPG. Researchers will collect neurobehavioral data in clinic and at home.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your OCD symptoms will be measured at 14 months after the intervention.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Neurophysiological Investigation of the Approach-avoidance Axis in OCD: Applications to Neuromodulation
At a glance
Conditions
Where it's being run
2 sites across 1 statesWho to contact
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What this trial measures
- Changes in OCD symptoms14 months
Response will be defined as 35% decrease in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) from baseline. The range is from 0 to 40 with a score of 0-7 indicating subclinical symptoms, 8-15 mild symptoms, 16-23 moderate symptoms, 24-31 severe symptoms, and 32-40 extreme symptoms.