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Mapping Brain Activity in Chronic Stroke with Hemiparesis

This study is looking for adults aged 18 and older who have experienced a stroke and have weakness on one side of their body (hemiparesis). The goal is to understand how the brain controls arm movement after a stroke. You will perform a simple shoulder movement task while undergoing an MRI scan. Researchers will use functional MRI (fMRI) to map brain activity and see which brain pathways are being used. This information could help develop better treatments for stroke recovery. The study aims to enroll 32 participants, and its current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 32 participants. It uses functional magnetic resonance imaging (fMRI) to observe brain activity during a shoulder movement task.
What's involved
You will perform short, unilateral shoulder abduction tasks while receiving visual feedback. You will also undergo an MRI scan.
Compensation
Not stated in the trial record.
Follow-up
Brain activity (BOLD activation) will be measured at 3 days to 3 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06598150

Mapping Corticoreticulospinal Motor Control in Chronic Hemiparetic Stroke

Recruiting
NAAges 18+InterventionalBasic science
Northwestern University
~32 participants
Updated 2025-10-01 on ClinicalTrials.gov
What's tested:Shoulder Abduction

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
BOLD activation
Measured over 3 days to 3 months

Conditions

Stroke
Hemiparesis

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Stroke

NCT06598150

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Northwestern University

    Chicago, Illinoisstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Molly G Bright, DPhil · PRINCIPAL_INVESTIGATOR · Northwestern University

Who to contact

Michelle Medina, BS
[email protected]
872-272-7687
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Adults aged at least 18y
Able to perform shoulder abduction task (confirmed during screening and initial examination)
Safe to undergo MRI
Able to follow visual instructions using MRI-compatible vision correction goggles
No brainstem or cerebellar lesions
No severe concurrent medical problems
Cognitive/attentional capacity to focus on a task
Able to communicate in English or Spanish
Have sustained only one unilateral subcortical, ischemic lesion in the territory supplied by the Middle Cerebral Artery (confirmed by clinical or radiological reports) at least one year prior to participation in this project
Paresis confined to one side, with moderate-to-severe motor impairment of the upper limb (Upper Extremity Fugl-Meyer score between 10 and 45).

Exclusion

MRI contraindications
Severe claustrophobia
Pregnant women
Prisoners
Vulnerable populations
Diagnosis/history of:
multiple sclerosis
brain tumor
brain radiation
traumatic brain injury
dementia
Parkinson's disease
Concurrent enrollment in an intervention study
Concurrent use of medications known to suppress central nervous system activity

What this trial measures

  • BOLD activation3 days to 3 months

    BOLD fMRI data will be analyzed to map neural activation associated with the shoulder abduction task.