Observational Study on Nivolumab for Atypical Nevi in Melanoma Patients

This observational study is looking at how a treatment called Nivolumab affects atypical (unusual) moles, also known as dysplastic nevi, in people who have had melanoma. Nivolumab is an immunotherapy drug that targets a protein called PD-1 on immune cells, helping your body fight cancer. Researchers want to see if Nivolumab can help prevent melanoma by changing these atypical moles. They will measure changes in the moles' color and appearance for up to 12 months. You could be eligible if you are at least 18 years old, have a history of melanoma (Stages IIB, IIC, IIIA, IIIB, or IIIC), and have at least two atypical moles that are 4mm or larger. The study aims to enroll 30 participants.

Study design
This is an observational study involving 30 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint measures changes for up to 12 months, suggesting follow-up for at least this duration.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06599619

Effects of Anti-PD1 Adjuvant Checkpoint Blockade Immunotherapy on Atypical/Dysplastic Nevi

Recruiting
Not specifiedAges 18+Observational
John Kirkwood
~30 participants
Updated 2026-01-26 on ClinicalTrials.gov
What's tested:Single agent, adjuvant anti-PD1 therapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in the aggregate pigmentation
Measured over Pre-treatment, up to 12 months
Melanoma
1 sites across 1 states
Pennsylvania1
  • John M Kirkwood, MD · PRINCIPAL_INVESTIGATOR · UPMC Hillman Cancer Center

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  • Change in the aggregate pigmentationPre-treatment, up to 12 months

    Percentage change in the total aggregate pigmentation including A/DN and benign melanocytic nevi. Percent change will be quantified from posterior trunk digital photographic images utilizing DermViz automated image comparison software.