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Cryoneurolysis for Pain After ACL Reconstruction

This study is looking at whether a procedure called Cryoneurolysis can help reduce the amount of pain medicine (opioids) needed after surgery to fix a torn ACL (anterior cruciate ligament). Cryoneurolysis uses extreme cold to temporarily block pain signals from certain nerves around the knee. If you join, you'll be randomly assigned to either receive standard care for your ACL surgery, or standard care plus Cryoneurolysis before your surgery. Researchers will then track how much opioid pain medicine you use for 12 weeks after your surgery. You may be able to join if you are 14 or older, speak English, are having an autograft ACL reconstruction, and haven't taken opioids before. The study plans to enroll 20 people.

Study design
This is an interventional study where participants are randomly assigned to one of two groups: standard care or standard care plus Cryoneurolysis. The study plans to enroll 20 participants.
What's involved
If you are in the Cryoneurolysis group, you will receive the procedure 7-10 days before your scheduled surgery. All participants will undergo standard ACL reconstruction and receive standard pain management.
Compensation
Not stated in the trial record.
Follow-up
Your opioid consumption will be measured at 1 week, 6 weeks, and 12 weeks after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06603051

The Effect of Pre-Operative Cryoneurolysis on Post-Operative Narcotic Consumption in Patients Undergoing Autograft ACL Reconstruction

Recruiting
NAAges 14+InterventionalTreatment
Virtua Health, Inc.
~20 participants
Updated 2026-05-12 on ClinicalTrials.gov
What's tested:Cryoneurolysis

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Post-operative opioid consumption
Measured over Measured at 1-week, 6-weeks, 12-weeks

Conditions

ACL Repair

Explore related trials

Injury of anterior cruciate ligament

NCT06603051

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Virtua Orthopedics Burlington

    Burlington, New Jerseystudy coordinator listed

    Recruiting

  • Virtua Orthopedics Cherry Hill

    Cherry Hill, New Jerseystudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

Sean Mc Millan, DO
[email protected]
(609)747-9200
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

\- Patients aged 14 and over
Patients who are patients within the PI's practice
Patients who can speak and read English
Patients undergoing autograft ACL reconstruction.
Patients who are opioid naïve

Exclusion

\- Under the age of 14
Non-English speaking/reading patients
Patients with Reynauds' syndrome
Patients with skin disorders or hypo-vascularity
Patients undergoing allograft ACL reconstruction.
Patients who consistently use opioids preoperatively

What this trial measures

  • Post-operative opioid consumptionMeasured at 1-week, 6-weeks, 12-weeks

    average daily morphine milliequivalents (MMEs) over the measured postoperative period