Observational Study on Antibodies and Cytokines in Chronic Granulomatous Disease

This study is looking at people with Chronic Granulomatous Disease (CGD) to understand more about their immune system. Researchers want to measure the levels of certain antibodies (proteins that fight infections) and cytokines (proteins that help control inflammation) in your blood. This will help them learn about how common these markers are in people with CGD. You could join if you have CGD, which means your doctor has confirmed that your white blood cells don't work properly (NADPH oxidase activity is ≤5% or you have a specific gene change). The study aims to find out the levels of total adenoviral-specific antibody (TAb) and adenoviral-specific neutralizing antibody (NAb) in your blood. This is an observational study, meaning researchers will collect information without giving you any new treatments. The study is currently unclear about its recruitment status and plans to include 60 participants.

Study design
This is an observational study that plans to include 60 participants. It is not a randomized or blinded study.
What's involved
Blood samples will be collected from you. The levels of certain antibodies and inflammatory cytokines will be measured from these samples.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints (antibody levels) are measured at 1 Day. It is not specified if there is follow-up beyond this.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06605378

Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease

Recruiting
Not specifiedAll AgesObservational
Ensoma
~60 participants
Updated 2026-08-17 on ClinicalTrials.gov

At a glance

Recruiting sites
50 of 52 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Total adenoviral-specific antibody (TAb) titer
Measured over 1 Day
+1 more outcome measured
Chronic Granulomatous Disease (CGD)

NCT06605378

Where you'd take part

This study runs at 52 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Home-based telemedicine

    Montgomery, Alabamastudy coordinator listed

    Recruiting

  • Home-based telemedicine

    Phoenix, Arizonastudy coordinator listed

    Recruiting

  • Home-based telemedicine

    Little Rock, Arkansasstudy coordinator listed

    Recruiting

  • Home-based telemedicine

    Sacramento, Californiastudy coordinator listed

    Recruiting

  • Home-based telemedicine

    Denver, Coloradostudy coordinator listed

    Recruiting

  • Home-based telemedicine

    Hartford, Connecticutstudy coordinator listed

    Recruiting

  • Home-based telemedicine

    Dover, Delawarestudy coordinator listed

    Recruiting

  • Home-based telemedicine

    Washington D.C., District of Columbiastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Opens a ready-to-send draft in your own email app — review before sending.

Want this trial checked against your situation?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

The participant must have been diagnosed with CGD based on the referring physician's confirmation that NADPH oxidase activity is ≤5% (i.e., the percentage of dihydrorhodamine-positive \[DHR+\] cells is ≤5% by flow cytometry) OR based on confirmed pathogenic mutation in a CGD associated gene (CYBB, CYBA, NCF1, NCF2, NCF4, or CYBC1).
The participant or the participant's legally authorized guardian or representative (if applicable) must be capable of giving signed informed consent.
The participant (with assistance from the participant's legally authorized guardian/representative or primary caregiver, if applicable) must be capable of complying with the requirements and restrictions listed in the protocol and informed consent form (ICF).

Exclusion

The participant has undergone an allogeneic bone marrow transplant or investigational gene therapy.
The participant is unable to comply with the sample collection procedure based on investigator judgment.
  • Total adenoviral-specific antibody (TAb) titer1 Day

    Level of total adenoviral-specific antibody in blood

  • Adenoviral-specific neutralizing antibody (NAb) titer1 Day

    Level of adenoviral-specific neutralizing antibodies in blood