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OPTIMAL Study: Diet and Brain/Heart Health

The OPTIMAL study is looking at how different diets affect your brain and heart health. It compares the MIND Diet, which focuses on foods that may protect against brain diseases, with a healthy American diet. The study wants to see if the MIND Diet improves your thinking skills (like attention and reaction time) over 12 weeks. You might be able to join if you are between 45 and 64 years old, have good vision, and don't have certain health conditions or allergies. The study is currently unclear on its recruitment status, but plans to enroll 72 participants.

Study design
This interventional study plans to enroll 72 participants. It compares the MIND Diet to a control diet, with participants not knowing which diet they are assigned to.
What's involved
You would eat a microwaveable meal or smoothie daily for 12 weeks, follow simple dietary guidance, complete online forms, and attend 4 in-person visits for computer tests, an eye test, heart rate/blood pressure checks, a DXA scan, and blood draws.
Compensation
Not stated in the trial record.
Follow-up
Your cognitive performance and heart health will be assessed at the beginning and end of the 12-week diet period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06605898

Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes (OPTIMAL)

Recruiting
NAAges 45–64Interventional
University of Illinois at Urbana-Champaign
~72 participants
Updated 2024-09-20 on ClinicalTrials.gov
What's tested:MIND DietControl Diet

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Attentional Accuracy
Measured over [Time Frame: 12 weeks (Baseline vs Follow-Up)]
+8 more outcomes measured

Conditions

Cognitive Change
Diet, Healthy
Metabolic Syndrome, Protection Against

Explore related trials

Metabolic Syndrome

Where it's being run

1 sites across 1 states
Illinois1

Study leadership

  • Naiman Khan, PhD · PRINCIPAL_INVESTIGATOR · University of Illinois Urbana-Champaign

Who to contact

Naiman Khan, PhD
[email protected]
2173001667
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

45-64 years of age
20/20 or corrected vision
No food allergies or intolerances
Not pregnant, lactating, or have given birth in the past 12 months
Do not smoke, use tobacco, or abuse drugs
Absence of liver or gastrointestinal diseases (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, and cancer
Not currently taking oral hypoglycemic agents, or insulin
No history of malabsorptive or bariatric surgery
Cognitively intact with no prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and/or Asperger's syndrome)
Able to consume the study meals
Not enrolled in another dietary, exercise, or medication study during the study.

Exclusion

Non-consent of participant
Above 64 or below 45 years of age
Vision not 20/20 or corrected
Food allergies or intolerances
Pregnant, lactating, or have given birth in the past 12 months
Smoke, use tobacco, or abuse drugs
Prior diagnosis of liver or gastrointestinal disease (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, or cancer
Currently taking oral hypoglycemic agents or insulin
History of malabsorptive or bariatric surgery
Cognitively impaired and/or prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and/or Asperger's syndrome)
Unable to consume the study meals
Concurrent enrollment in another dietary, exercise, or medication study

What this trial measures

  • Attentional Accuracy[Time Frame: 12 weeks (Baseline vs Follow-Up)]

    Changes in accuracy (%) between groups using a computerized flanker task.

  • Attentional Reaction Time[Time Frame: 12 weeks (Baseline vs Follow-Up)]

    Changes in reaction time (ms) between groups using a computerized flanker task.

  • Attentional Resource Allocation[Time Frame: 12 weeks (Baseline vs Follow-Up)]

    Changes in P3 event related potential amplitude (microvolts) between groups using a computerized flanker task.

  • Attentional Processing Speed[Time Frame: 12 weeks (Baseline vs Follow-Up)]

    Changes in P3 event related potential latency (ms) between groups using a computerized flanker task.

  • Fasting Blood Glucose[Time Frame: 12 weeks (Baseline vs Follow-Up)]

    Changes in fasting blood glucose concentration (mg/dL) between groups.

  • Fasting Blood Triglycerides[Time Frame: 12 weeks (Baseline vs Follow-Up)]

    Changes in fasting blood triglyceride concentration (mg/dL) between groups.

  • Fasting Blood HDL[Time Frame: 12 weeks (Baseline vs Follow-Up)]

    Changes in fasting blood HDL concentration (mg/dL) between groups.

  • Blood Pressure[Time Frame: 12 weeks (Baseline vs Follow-Up)]

    Changes in systolic and diastolic blood pressure (mmHg) between groups

  • Waist Circumference[Time Frame: 12 weeks (Baseline vs Follow-Up)]

    Changes in waist circumference (cm) between groups.