Exercise and Monitoring for Muscle Weakness in CKD
This study is for Veterans aged 55 and older with stage 3 or 4 chronic kidney disease (CKD), which means their kidneys aren't working as well as they should. It aims to help people who experience muscle weakness after being in the hospital. Participants will do exercises two days a week for 16 weeks, focusing on squats, shoulder presses, seated rows, and bicep curls. Researchers will measure muscle thickness, function, and strength at 4 and 10 months to see if the exercise program helps. You cannot join if you have uncontrolled high blood pressure, a recent heart event, severe heart failure, or certain other health issues. The study is currently recruiting 250 participants at VA sites in Denver and Baltimore.
- Study design
- This interventional study plans to enroll 250 participants. It is not specified if it is randomized or blinded.
- What's involved
- Participants will exercise two days a week for 16 weeks. Muscle health, strength, and mobility will be assessed at the start, and then at 4 and 10 months.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for at least 10 months after starting the study, with measurements taken at 4 and 10 months.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength
At a glance
Conditions
NCT06607913
Where you'd take part
This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Baltimore, Marylandstudy coordinator listed
Recruiting
Rocky Mountain Regional VA Medical Center, Aurora, CO
Aurora, Coloradostudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Michael Harris-Love, DSc MPT BS · PRINCIPAL_INVESTIGATOR · Rocky Mountain Regional VA Medical Center, Aurora, CO
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Vastus Lateralis Muscle Thickness4 month, 10 month
A measure of the Vastus Lateralis muscle will be examined using ultrasound technology to determine the muscle size, quality, and composition. Post-intervention levels will be compared to 6 months after the cessation of the intervention.
- Function4 month, 10 month
The short physical performance battery test is a function measure that utilizes 3 tasks scores 0-4 (total possible score of 12) to determine functional status and lower extremity function. Pre-test scores will be compared to post intervention test scores.
- Lower Extremity Strength - Isometric Strength4 month, 10 month
A measures of maximal isometric muscle strength produced in knee extensor muscles will be assessed with a Biodex device. Post-intervention levels will be compared to 6 months after the cessation of exercise.
- Upper Extremity Strength - Grip Strength4 month, 10 month
A measures of maximal isometric muscle strength produced in upper extremity muscles will be assessed by grip strength. Post-intervention levels will be compared to 6 months after the cessation of exercise.