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High-intensity training for chronic stroke recovery

This study is looking at how often people with chronic stroke (stroke that happened more than 6 months ago) should do high-intensity gait training (walking practice that gets your heart rate up) to improve their walking. You would also receive physical activity coaching to help you walk more on days you don't have training. The study wants to see if doing this training more often (6 weeks) or less often (12 weeks) makes a difference in how far you can walk in 6 minutes. To join, you need to be between 18 and 85 years old, have had a stroke that caused weakness on one side, and be able to follow simple commands and walk a short distance. The study is currently unclear on its recruitment status.

Study design
This study will involve 40 participants and uses a randomized approach, meaning you'd be assigned by chance to one of two groups: high-frequency or low-frequency training.
What's involved
You would have 18 training sessions over either 6 or 12 weeks, with follow-up testing at 6, 12, and 24 weeks.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 24 weeks after starting the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06612723

High vs Low-frequency of High-intensity Training in Chronic Stroke

Recruiting
NAAges 18–85InterventionalTreatment
Indiana University
~40 participants
Updated 2026-01-27 on ClinicalTrials.gov
What's tested:high-intensity gait trainingPhysical activity coaching

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
6-minute walk test
Measured over After 12 weeks

Conditions

Stroke

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Stroke

NCT06612723

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Rehabilitation Hospital of Indiana

    Indianapolis, Indianastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Thomas G Hornby, PhD · PRINCIPAL_INVESTIGATOR · Indiana University

Who to contact

Christopher Henderson, PhD
[email protected]
317-329-2353
Email the study team

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Eligibility criteria

Inclusion

Unilateral deficits following stroke \> 6 months prior; however individuals \> 4 months post-stroke are eligible for consenting, but final eligibility and potential enrollment will not occur until \> 6 months
Age 18-85
Weight \< 350 pounds
Able to follow 3-step commands
Able to ambulate with self-selected gait speeds between 0.10-1.0 m/s without physical assistance, but with below knee bracing and/or assistive device as needed
Lower extremity Fugl-Meyer \< 34
Medical clearance to participate

Exclusion

Evidence of cerebellar ataxia
Uncontrolled cardiopulmonary or metabolic disease that limits exercise participation, active heterotopic ossification, recurrent history of lower extremity fractures, previous orthopedic or other peripheral or central neurologic injury that may impair locomotor activities such that, in the judgement of the PI, could compromise the safety of the participant, limit the ability to complete the study, or compromise the objectives of the study.
Currently participating in other physical therapy
\>50 units of Botox in the lower extremity OR in the lower extremity, but above the knee if the participant wears an ankle-foot-orthosis (AFO) within the past three months

What this trial measures

  • 6-minute walk testAfter 12 weeks

    Individuals will be asked to "cover as much ground as possible" over 6 mins. Heart rate will additionally be measured during this assessment (distance in m)