Optimizing Brain Stimulation Parameters for Epilepsy

This study aims to find the best settings for brain stimulation devices used to treat epilepsy. If you have a brain stimulation device (Deep Brain Stimulation or DBS) targeting the anterior nucleus of the thalamus, you might be able to join. The study will compare two different stimulation settings: Set A (145 Hz high frequency stimulation) and Set B (low frequency stimulation, less than 40 Hz). You would receive one setting for three months, then the other for three months. Researchers will measure how often you have seizures (seizure burden) at different times to see which setting works better. The study is currently unclear on its recruitment status.

Study design
This study plans to enroll 30 participants. It is an interventional study comparing two different stimulation parameter sets.
What's involved
You would receive one stimulation setting for three months, then switch to the other setting for another three months. Seizure burden will be measured at baseline, 4 months, 7 months, and 12 months.
Compensation
Not stated in the trial record.
Follow-up
Your seizure burden will be measured at 4 months, 7 months, and 12 months after the study begins.

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NCT06617845

Optimizing Brain Stimulation Parameters

Recruiting
NAAges 6+InterventionalTreatment
Mayo Clinic
~30 participants
Updated 2025-10-14 on ClinicalTrials.gov
What's tested:Stimulation Set A and B

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Seizure burden
Measured over Baseline, 4 months, 7 months, 12 months
Epilepsy; Seizure
1 sites across 1 states
Minnesota1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patients who are implanted with a brain stimulation device targeting the anterior nucleus of the thalamus per Mayo Clinic standard of care

Exclusion

Patients for whom clinical follow-up is not expected during the initial 6-8 months following implant
  • Seizure burdenBaseline, 4 months, 7 months, 12 months

    Using the Mayo Epilepsy Short Assessment as well as patient diaries, seizure frequency is determined.