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Resistance Exercise and Cardiovascular Health

This study is looking at how different amounts of resistance exercise (like weightlifting) affect your heart health. Researchers want to see if adding 30, 60, or 120 minutes of resistance exercise each week to a regular aerobic exercise routine (like walking or cycling) can improve your risk of heart disease. You might be able to join if you are between 40 and 99 years old, don't smoke, are overweight or obese, and don't currently exercise much. The study will measure changes in your overall cardiovascular (heart and blood vessel) risk score after 6 months to see if the exercise programs are successful.

Study design
This is an interventional study planning to enroll 240 participants. You would be randomly assigned to one of four groups, each with a different amount of weekly resistance exercise.
What's involved
You would participate for one year, attending two exercise sessions per week. You'll also have physical exams at the start, 6 months, and 12 months, and track daily steps, food intake, and activity.
Compensation
Not stated in the trial record.
Follow-up
Your cardiovascular risk score will be assessed at 6 months and 12 months after starting the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06619444

Dose-Response to Resistance Exercise on Cardiovascular Health

Recruiting
NAAges 40+InterventionalTreatment
University of Pittsburgh
~240 participants
Updated 2026-07-07 on ClinicalTrials.gov
What's tested:Aerobic exercise only30 min of resistance exercise60 min of resistance exercise120 min of resistance exercise

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change from baseline in composite cardiovascular risk score at 6 months
Measured over Baseline and 6 months

Conditions

Cardiovascular Risk

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Cardiovascular Risk

NCT06619444

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Physical Activity Research Center (PARC)

    Pittsburgh, Pennsylvaniastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Duck-chul Lee, PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

Duck-chul Lee, PhD
[email protected]
412-383-4004
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Non-Smoker
Overweight or Obese: Body Mass Index 25-43 kg/m2
Inactive: not meeting the US resistance and aerobic exercise guidelines over the last 6 months
Walking \<7,000 steps/day at baseline
Capable of performing the required exercise training

Exclusion

Unstable coronary heart disease or heart failure
Uncontrolled arrhythmias or severe aortic stenosis
Acute myocarditis, endocarditis, or pericarditis
Cancer, requiring treatment in the past 5 years
Autoimmune diseases, affecting immune system
Plans to be away ≥4 weeks in the next 1 year
Pregnancy/anticipated pregnancy during the study
Other medical condition that is life-threatening or can interfere with or be aggravated by the exercise training
Uncontrolled Diabetes (HbA1c ≥8.0),
Hypertensive Blood Pressure ≥160 mm Hg Systolic and/or 100 mm Hg Diastolic,
Major risk factors for coronary heart disease
Uncontrolled diabetes or musculoskeletal limitations

What this trial measures

  • Change from baseline in composite cardiovascular risk score at 6 monthsBaseline and 6 months

    The primary outcome will be change from baseline to 6 months in the average composite cardiovascular disease (CVD) risk z-score comprising systolic Blood pressure (SBP), Low-Density lipoprotein cholesterol (LDL-C), fasting glucose, and percent body fat; lower scores indicate better overall CVD risk profile. Each CVD risk factor at baseline and 6 months will be individually standardized to sex-specific z -scores with a mean of 0 and standard deviation (SD) of 1 based on the formula (observed value-mean)/SD for each participant, using the baseline means and SDs from the entire sample.