Brain Function Monitoring During Surgery

This study is looking at how well the Sedline Brain Function Monitor works during surgery. Doctors will use information from this monitor to adjust the amount of anesthesia you receive. The goal is to see if monitoring brain activity during surgery leads to a faster recovery, earlier discharge from the hospital, and fewer side effects. Researchers also want to understand if men and women respond to anesthesia similarly, both with and without this brain monitoring. You might be able to join if you are between 18 and 45 years old, are having a surgery lasting 60 to 240 minutes under general anesthesia, and are generally healthy or have a severe disease. The study is currently unclear on its recruitment status.

Study design: This is an interventional study planning to enroll 100 participants. It will compare recovery outcomes when the Sedline Brain Function Monitor is used during surgery.
What's involved: Not specified in the trial record.
Compensation: Not stated in the trial record.
Follow-up: Your recovery time will be measured for up to 3 hours after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

Brain Function Monitoring During Surgery

Completed

NAAges 18–45InterventionalSupportive care

University of Chicago

~100 participants

Updated 2026-08-12 on ClinicalTrials.gov

What's tested:Sedline Brain Function Monitor

At a glance

Recruiting sites

0 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Speed of Recovery Time

Measured over Up to 3 hours

Conditions

Surgery

Where it's being run

1 sites across 1 states

Illinois1

Study leadership

Zheng Xie, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Chicago

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

American Society of Anesthesiology Physical Status Classification Grade of 1(normal, healthy patient) to Grade 3 (patient with severe disease)

Between ages 18-45 years old

Planned surgery duration between 60-240 minutes General-endotracheal-tube-anesthesia or general anesthesia with laryngeal mask airway

Subjects capable of giving informed consent or

Subjects who have an acceptable surrogate capable of giving consent on behalf of the subject

All contraception methods will be allowable for any subject in this study. Participants may opt-out of a pregnancy test if they would prefer to proceed with surgery without one.

Exclusion

American Society of Anesthesiology Physical Status Classification Grade of 4,5,6 (diseases that are life threatening or no possibility of survival)

Listed allergies to any commonly used anesthetic agents

History of seizures, as a seizure while using brain monitoring may influence the anesthesia provider in a way that is not aligned with the purpose of this study

Any patient undergoing emergency surgery, as can not be ensured that consent will be able to be properly obtained

Patient refusal to participate in study

Any patient undergoing surgery that would prevent placement of the Sedline monitor leads (for example - surgery on the patient's forehead/scalp)

Patients who receive neuraxial anesthesia or a peripheral nerve block as part of their anesthetic

Patients who are taking gender-affirming hormonal medications, as this can affect the response to anesthetics

The duration of surgery scheduled \<60 minutes

What this trial measures

Speed of Recovery TimeUp to 3 hours
The primary endpoint is the speed of recovery time, measured from the end time of the surgery, to the time of meeting the criteria for pediatric acute care unit (PACU) discharge. These criteria are lack of nausea/vomiting, grogginess and the level of pain; with 0 being no pain and 10 being severe pain.

Trialytics