NCT06619964
Developing Evidence to Inform Regulatory Policy on Nicotine Content in E-Liquids
Enrolling by Invitation
Not specifiedAges 21+ObservationalRochester Institute of TechnologyInvestigator-initiated
~120 participants
Updated 2026-01-15 on ClinicalTrials.gov
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Mean daily salivary cotinine
Measured over From enrollment to the end of observation at 2 weeks.
Conditions
Where it's being run
1 sites across 1 statesNew York1
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Age 21 yrs or older
Pod-style or pen-style users, not adjustable for power or airflow, nicotine greater than 0 mg/mL
Current everyday users
Use history of at least 30 days
No current use of combustible tobacco product, or nicotine replacement therapy
CO less than 6 ppm at intake
No plans to quit tobacco use in the next 30 days
Exclusion
History of acute or chronic asthma
Previous diagnosis of cancer
Other chronic medical conditions
Use of chronic prescription medications
Pneumonia in prior six weeks
Upper respiratory tract infection or other febrile illness in previous 2 weeks
On antioxidants or anti-inflammatory therapy
Pregnant women or women who intend to become pregnant
What this trial measures
- Mean daily salivary cotinineFrom enrollment to the end of observation at 2 weeks.
Nicotine exposure as indicated by mean daily salivary cotinine will be compared for lower versus higher nicotine strength regular ecig users, on a continuous scale. This will determine the extent to which reduced nicotine products result in lower nicotine exposure.