Transnasal Sphenopalatine Ganglion Block for Headache After Brain Bleed

This study is testing a treatment for headaches that happen after a subarachnoid hemorrhage (SAH), which is a type of bleeding in the brain. Researchers want to see if adding a "transnasal sphenopalatine ganglion block" to standard pain medication helps reduce headache severity more than medication alone. This block involves using a device called Tx360 to deliver bupivacaine (a numbing medicine) and sometimes dexamethasone (an anti-inflammatory medicine) into your nose to reach a nerve cluster. The study is looking for 40 participants, aged 18 to 100, who have had an acute SAH and can describe their pain. You cannot join if you are pregnant, have an unsecured aneurysm, or cannot verbalize pain. The main goal is to see if this treatment reduces your pain scores. The study status is currently unclear.

Study design
This is a randomized controlled pilot study involving 40 participants. You would be assigned by chance to receive either standard pain medication or standard medication plus the sphenopalatine ganglion block.
What's involved
You would receive the sphenopalatine ganglion block procedure if you are in that group. Your pain scores and opioid use would be monitored from enrollment until ICU discharge, up to 14 days. Individual participation lasts up to four weeks.
Compensation
Not stated in the trial record.
Follow-up
Your pain scores will be measured from enrollment until ICU discharge, up to 14 days.

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NCT06621329

Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated Headache

Recruiting
PHASE2Ages 18+InterventionalTreatment
University of California, Davis
~40 participants
Updated 2026-08-18 on ClinicalTrials.gov
What's tested:Transnasal sphenopalatine ganglion block

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Numerical pain rating scale
Measured over From enrollment until ICU discharge, up to 14 days
SAH (Subarachnoid Hemorrhage)
Headache
1 sites across 1 states
California1
  • Christine Picinich, MS, AGACNP-BC, CCRN · PRINCIPAL_INVESTIGATOR · University of California, Davis

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Eligibility criteria

Inclusion

Acute subarachnoid hemorrhage
Age greater than 18 years
Secured aneurysm
Patient can verbalize pain score to clinician, nurse, medical translator, or surrogate decision
maker
Patient or surrogate decision maker is available to consent

Exclusion

Less than 18 years old
Unsecured aneurysm
Pregnant or lactating
Prisoner
Unable to verbalize pain score to clinician, nurse, medical translator, or surrogate decision maker
Nasal or facial trauma or surgery within the last three months
Allergy to lidocaine, bupivacaine, or dexamethasone
Patient is unable to consent and no available surrogate decision maker
  • Numerical pain rating scaleFrom enrollment until ICU discharge, up to 14 days

    Pain scores will be obtained at regular intervals to compare pain control between the two arms. Pain scores will be collected multiple times throughout each ICU day, up to ICU day 14.