This observational study is looking at how the body's nervous system responds in people with obesity. Specifically, it's investigating if a process called sympathetic transduction (how blood vessels react to nerve signals) is different in obese individuals with insulin resistance. The study will test if giving ascorbic acid (vitamin C) can change this response. You may be able to join if you are 18-79 years old, have obesity (BMI over 25), and elevated insulin resistance. The main goal is to measure sympathetic transduction after 2 hours. The current status of this study is unclear.

Study design

This is a randomized, double-blind, placebo-controlled study involving 60 participants. You will receive either ascorbic acid or a placebo, and then the other treatment at a later visit.

What's involved

You will have a total of 3 visits to the laboratory over approximately 5 weeks. You must also be willing to stop taking vitamin C or E supplements or omega-3 fatty acids for 2 weeks before the study begins.

Compensation

Not stated in the trial record.

Follow-up

The primary outcome, sympathetic transduction, is measured at 2 hours after treatment. The study involves visits over approximately 5 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.