Type 1 Diabetes REst for Metabolic Health Study
This study is looking at whether improving sleep can help teenagers with type 1 diabetes (T1D) improve their heart health and how their body uses sugar. Researchers will have participants follow a sleep schedule that gives them at least one more hour in bed each night, along with taking 500mcg of melatonin two hours before bedtime. You might be able to join if you are a high school student between 14 and 19 years old with T1D, use an insulin pump, and typically sleep less than 7 hours on school nights. The study will measure changes in how your body responds to insulin (insulin sensitivity), how well your blood sugar is controlled (glycemic control), and your heart health (cardiovascular function) after one month of this sleep intervention. The current status of this study is unclear, and it plans to enroll 50 participants.
- Study design
- This is an interventional study planning to enroll 50 participants. It will compare participants' health after a month of typical sleep to a month of increased sleep and melatonin.
- What's involved
- Participants will follow a prescribed sleep schedule and take melatonin for one month. Measurements of insulin sensitivity, cardiovascular function, and glycemic control will be taken at the start and end of this month.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for one month after the intervention to assess changes in insulin sensitivity, cardiovascular function, and glycemic control.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Type 1 Diabetes REst for Metabolic Health
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Stacey L Simon, PhD · PRINCIPAL_INVESTIGATOR · University of Colorado, Denver
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Insulin SensitivityBaseline (following 1 month typical sleep) and following 1 month intervention
Steady-state glucose infusion rate (M) normalized to free fat mass (FFM) and to steady-state insulin (M/I, \[mg/kg FFM/min\]/insulin) measured with hyperinsulinemic euglycemic clamp
- Cardiovascular FunctionBaseline (following 1 month typical sleep) and following 1 month intervention
Value of central aortic stiffness from cardiovascular MRI
- Glycemic ControlBaseline (following 1 month typical sleep) and following 1 month intervention
Value of mean sensor glucose assessed with continuous glucose monitor