NCT06628037
SN514-066b Enzyme in Deep Partial Thickness Burns
Enrolling by Invitation
PHASE1Ages 18–80InterventionalTreatmentSERDA bv
~27 participants
Updated 2025-05-13 on ClinicalTrials.gov
What's tested:SN514-066b
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Determine the maximum tolerated concentration of SN514 gel when applied topically to deep partial thickness burn wounds
Measured over Daily x 7days
Conditions
Where it's being run
1 sites across 1 statesTexas1
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.
Eligibility criteria
Exclusion
Electrical or chemical etiology
Pre-enrollment escharotomy
Area is devoid of circulation
Located on the face, perineum or genitalia
Clinical evidence of wound infection 3. Poorly controlled diabetes mellitus (HbA1c \>12%) 4. BMI greater than 40 kg/m2 5. Cardio-pulmonary disease (MI within 6 months prior to injury, severe or unstable ischemic heart disease, severe or unstable heart failure, severe pulmonary hypertension, severe COPD or pre-existing oxygen-dependent pulmonary diseases, severe broncho-pneumonia within 1 month prior to injury, steroid dependent asthma, or uncontrolled asthma) 6. Pre-existing diseases which interfere with circulation (severe peripheral vascular disease, severe circulatory edema and/or lymphedema, regional lymph nodes dissection, significant varicose veins) 7. Any conditions that would preclude safe treatment or adding further risk to the basic acute burn trauma (such as severe immuno-compromising diseases, life threatening trauma, severe pre-existing coagulation disorder, severe cardiovascular disorder, significant pulmonary disorder, significant liver disorder including post alcoholic abuse impaired function or neoplastic disease, blast injury)
What this trial measures
- Determine the maximum tolerated concentration of SN514 gel when applied topically to deep partial thickness burn woundsDaily x 7days
Number of participants with treatment-related adverse events of Grade 3 or higher as assessed using the Common Terminology Criteria for Adverse Events (CTCAE) v5.0, where a higher grade on the scale of 1 to 5 is a worse outcome.