Auditory Plasticity Training for Mild Traumatic Brain Injury
This study is looking at whether special training exercises can help people with mild traumatic brain injury (mTBI) hear better. Sometimes, mTBI can make it hard to hear in noisy places or tell where sounds are coming from. Researchers are testing two types of training: Speech in Noise Training and Spatial Hearing Training. They want to see if these exercises, which have helped healthy people, can also improve hearing for those with mTBI. Success would mean participants show improvement in their hearing scores and brain responses related to hearing. This study plans to enroll 80 participants and is currently unclear on its recruitment status. You may be able to join if you are between 18 and 55 years old, speak English as your primary language, and have a history of mTBI.
- Study design
- This interventional study plans to enroll 80 participants. It uses different training groups, including active control groups and a waitlist control group.
- What's involved
- You would participate in training at home over 8 days, with up to two 10-minute sessions each day for a total of 15 sessions. Some groups will also have in-person training sessions.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your hearing and brain responses will be measured from the start of the study up to 1 month and 10 days later.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Auditory Plasticity Training
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Rocio Norman, PhD · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center at San Antonio
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in Composite Hearing in Noise ScoreBaseline to 1 month + 10 days
The composite score will be the averaging (equal weighting) of z-scores from two tests: Spatial Release from Masking and Digits in Noise. Each test uses measures of decibels (dB), where smaller dB values indicate better performance.
- Change in Frequency Following Response (FFR): Cross Correlation of FFR and StimulusBaseline to 1 month + 10days
The time point of maximum correlation between the FFR and stimulus waveforms will be calculated. Larger correlation values indicate a more precise neural representation of the stimulus. A Fisher r-to-z transformation will be used to normalize the distribution of correlation values.
- Change in Frequency Following Response : Amplitude of stimulus fundamental frequencyTime Frame: Baseline to 1 month + 10days
The amplitude of the fundamental frequency will be defined using fast Fourier-transforms, and measured in microvolts. Larger values indicate greater amplitudes.
- Change in Spatial Hearing: Sound localization PrecisionBaseline to 1 month + 4 days
Sound localization precision will be measured as the absolute difference (in degrees) between the locations of the pointer and the sound target location in the horizontal plane. Smaller values indicate better spatial hearing precision.
- Change in Spatial Hearing: percent of front/back confusions.Baseline to 1 month + 4 days
Localization errors \> 45° that cross the interaural axis will be categorized as front/back confusions. The percentage of Front/back confusions among all trials will be measured, and larger percentages indicate worse spatial hearing.
- Change in P300 amplitude.Baseline to 1 month + 4 days
Amplitude of the P300 event-related potential in response to target sounds will be measured (in microvolts). Larger amplitudes indicate better spatial attention processing.