This study is looking at how blood vessels in the brain respond to changes in blood flow. Researchers will measure blood flow and blood velocity in the brain using MRI (magnetic resonance imaging) while participants perform breathing exercises and a simulated change in body position. You might receive either prazosin, a drug, or a placebo (an inactive substance). The study aims to understand why some older adults experience a faster decline in brain blood flow, which could increase their risk of memory problems. To join, you need to be between 55 and 69 years old, a non-smoker, and meet certain health and physical requirements. The study plans to enroll 36 participants, but its current recruitment status is unclear.

Study design

This is an interventional study planning to enroll 36 participants. It is not specified if it is randomized or blinded.

What's involved

You would undergo an MRI scan while performing breathing and a simulated postural change task. You would also receive a dose of prazosin or a placebo. These measurements will occur over two study visits, each lasting up to 240 minutes.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoints are measured at two study visits, up to 240 minutes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.