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Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort

This study is looking at how blood vessels in the brain respond to changes in blood flow in younger adults (ages 20-40). Researchers will use MRI scans to measure brain blood flow while participants do breathing exercises and simulated changes in body position. You might receive either prazosin, a medication, or a placebo (an inactive substance) during the study. The main goal is to see how blood velocity and blood flow in the brain change over two study visits, each lasting up to 240 minutes. We are currently unclear on the recruitment status for this study, which aims to enroll 36 participants.

Study design
This interventional study plans to enroll 36 participants. It involves MRI scans and administering either prazosin or a placebo.
What's involved
You would undergo an MRI scan while performing breathing and simulated postural change tasks, and receive either prazosin or a placebo. This will occur over two study visits, each lasting up to 240 minutes.
Compensation
Not stated in the trial record.
Follow-up
Changes in blood velocity and blood flow will be measured at two study visits, up to 240 minutes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06629090

Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort

Recruiting
PHASE2Ages 20–40InterventionalBasic science
University of Wisconsin, Madison
~36 participants
Updated 2026-07-06 on ClinicalTrials.gov
What's tested:MRIPrazosinPlacebo

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in blood velocity
Measured over Two study visits, up to 240 minutes
+1 more outcome measured

Conditions

Magnetic Resonance Imaging
Cerebrovascular Circulation

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Healthy Volunteers

NCT06629090

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • University of Wisconsin

    Madison, Wisconsinstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Jill Barnes, PhD · PRINCIPAL_INVESTIGATOR · UW Madison

Who to contact

Anna Howery
[email protected]
608-262-9572
Email the study team

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Eligibility criteria

Inclusion

Between the ages of 20-40 years
Have a BMI ≤34.5 kg/m2
are less than 72 in (182.88 cm) height
Nonsmoker

Exclusion

Diagnosis of Mild Cognitive Impairment (MCI) or Alzheimer's disease (AD)
History or evidence of hepatic disease, hematological disease, or peripheral vascular disease; severe kidney injury requiring hemodialysis
History of cardiovascular disease including: severe congestive heart failure, coronary artery disease, ischemic heart disease (stents, coronary artery bypass grafts) and tachycardia
Uncontrolled hypertension
History of clinically significant ischemic or hemorrhagic stroke, or significant cerebrovascular disease
Severe untreated obstructive sleep apnea
History of diabetes with HbA1c greater than 9.5 percent
Major neurologic disorders other than dementia (e.g., MS, ALS, brain surgery, etc.)
Current or recent (less than1 year) major psychiatric condition (Axis I) or addictive disorders
Significant surgical history
Other significant medical conditions at investigators' discretion
Contraindications to MRI
Prescribed medications that interfere with prazosin
Lactose allergy
lower body will not fit in lower body negative pressure (LBNP) chamber (regardless of overall height and BMI)

What this trial measures

  • Change in blood velocityTwo study visits, up to 240 minutes

    The change in blood velocity during breathing and simulated postural change tasks will be measured with MRI

  • Change in blood flowTwo study visits, up to 240 minutes

    The change in intracranial blood flow during breathing and simulated postural change tasks will be measured with MRI