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Observational Study of Shear Wave Elastography for Brain Tumor Stiffness

This study is looking at a new way to measure the stiffness of brain tissue and tumors during surgery. It uses a special ultrasound called Intraoperative Shear Wave Elastography Ultrasound (ISWEU) to see if there are differences in stiffness between healthy brain tissue and tumor tissue. The goal is to see if this method is practical to use in people and if it could help guide surgeons in the future. You might be able to join if you are at least 18 years old and are having surgery for a new or returning brain tumor that is located in an area where the ultrasound probe can be easily used. The study is currently observational, meaning it involves watching and measuring during your standard surgery, not giving a new treatment. We don't know the current recruitment status.

Study design
This is an observational study with a planned enrollment of 30 participants. It is not testing a new drug or treatment.
What's involved
You would undergo shear wave elastography ultrasound for 10-15 minutes during your standard surgery.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06630338

Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements

Not Yet Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~30 participants
Updated 2026-03-27 on ClinicalTrials.gov
What's tested:Non-Interventional Study

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility of utilizing Intraoperative Shear Wave Elastography Ultrasound (ISWEU) measurements intraoperatively and in the human brain to measure tissue stiffness.
Measured over At baseline

Conditions

Brain Tumor
Recurrent Brain Tumor
Brain Neoplasm
Recurrent Brain Neoplasm

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Brain Neoplasm

Where it's being run

1 sites across 1 states
Florida1

Study leadership

  • Alfredo Quinones-Hinojosa, MD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Clinical Trials Referral Office
[email protected]
855-776-0015
Email the study team

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Eligibility criteria

Inclusion

Patients must be at least 18 years old.
Patients must have planned surgery for resection of a newly diagnosed or recurrent brain tumors.
Patients with tumors located in the brain cortex or superficial white matter in which introduction of the ultrasound probe is straightforward and does not pose a risk for intraoperative complications.
Patients must have a Karnofsky performance status ≥ 60%.
Patient or legally authorized representative (LAR) willing to provide written informed consent.

Exclusion

Patients with deep-seated brain tumors in which introduction of the ultrasound probe poses an increased risk.
Patients with a history of any brain infections.
Patients with implanted devices.
Patients with any other neurological/neurosurgical disease that could affect tissue stiffness.
Patients with any other structural brain defect that could affect tissue stiffness.

What this trial measures

  • Feasibility of utilizing Intraoperative Shear Wave Elastography Ultrasound (ISWEU) measurements intraoperatively and in the human brain to measure tissue stiffness.At baseline

    After intraoperative measurement of brain stiffness using ISWEU, analysis will be conducted after each procedure by determining the tissue stiffness from different areas (tumor core, peritumoral brain zone, and non-cancerous brain tissue) and comparing the tumor stiffness between patients. Reviewers will determine whether ISWEU is feasible to be used as a tool to influence surgical decision.