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NCT06633198

Heat, Microvascular Function and Aging

Active, Not Recruiting
EARLY_PHASE1Ages 18–80InterventionalBasic science
William Hughes
~20 participants
Updated 2026-07-09 on ClinicalTrials.gov
What's tested:Passive HeatingL-NAME

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in cutaneous microvascular function
Measured over Baseline, 60 minutes post I/R, and 60 minutes post hot water immersion + I/R injury

Conditions

Aging

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Aging

NCT06633198

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Medical College of Wisconsin

    Milwaukee, Wisconsinno site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Participants must be between 18-80 yrs. of age

Exclusion

Cardiovascular Risk Factors
Uncontrolled/unmanaged hypertension and/or use of current anti-hypertensive therapy
Current Tobacco product use or within last 6 months
BMI greater than 30
Hyperlipidemia - diagnosed and/or taking medications to manage
Hypercholesterolemia - diagnosed and/or taking medications to manage (e.g. statins)
Type 1 or Type 2 Diabetes
Use of anti-coagulant or anti-platelet drugs
Use of beta blockers
Symptomatic coronary artery disease
Diagnosed Heart Failure (Any classification above Class I as defined by NY Heart Association)
Diagnosed renal impairment Renal impairment defined, according to National Kidney Foundation as abnormalities of kidney structure or function, present for greater than 3 months, including:
Albuminuria (ACR ≥ 30 mg/g)
Urine sediment abnormalities
Electrolyte and other abnormalities due to tubular disorders
Structural abnormalities detected by imaging
History of kidney transplantation
Decreased glomerular filtration rate (GFP \< 60 mL/min/1.73 m2)
Current Hormone Replacement Therapy Use
History of retinopathy
Documented neuromuscular disorders
Porphyria Cutanea Tarda (blistering of skin to sun; photosensitivity)
Pregnancy (Young Female subjects)
Allergies to povidone iodine
Tattoos on lower arm (forearm)
Use of erectile dysfunction medication in the past 6 months
Use of topical/non-topical steroids in last 6 months (e.g. cortisone cream)
Active anti-cancer treatment or treatment within last 12 months
Active COVID-19 or within the past 3 months
Gender Reassignment Therapy

What this trial measures

  • Change in cutaneous microvascular functionBaseline, 60 minutes post I/R, and 60 minutes post hot water immersion + I/R injury

    Change in cutaneous microvascular function assessed via microdialysis infusion of acetylcholine (dose response) in the presence and absence of L-NAME to test the dependency upon NO to elicit vasodilation.