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Immune Status After Being on Call for 24 Hours

This observational study is looking at how sleep deprivation affects the immune system of surgery residents. Researchers will collect blood samples to understand changes in immune cells before and after a 24-hour shift, and after a month of being "on call." Participants will also wear an Actigraph (GT9X-BT) Monitor for a week to track their steps, sleep, and heart rate. The study aims to see if 24-hour shifts lead to an increased inflammatory response and a weaker immune system. They plan to enroll 60 healthy surgery residents, aged 18 and older, of any gender or ethnicity.

Study design
This is an observational study with a planned enrollment of 60 healthy surgery residents. It is not a treatment study, but rather observes changes in immune cells.
What's involved
You would provide blood samples and wear an Actigraph monitor for one week. The monitor will be returned at visit 5 (day 30) of the study.
Compensation
Not stated in the trial record.
Follow-up
Immune cell changes will be measured at 24 hours. The Actigraph monitor is returned at day 30.

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NCT06636318

Immune Status After Being on Call for 24 Hrs

Recruiting
Not specifiedAges 18+Observational
University of Chicago
~60 participants
Updated 2025-12-09 on ClinicalTrials.gov
What's tested:Blood Sample CollectionActigraph (GT9X-BT) Monitor

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Characterization of the phenotype and function of immune cells using flow cytometry
Measured over 24 hours

Conditions

Sleep Deprivation

Explore related trials

Sleep deprivation

Where it's being run

1 sites across 1 states
Illinois1

Study leadership

  • Angelica Perez-Gutierrez, MD · PRINCIPAL_INVESTIGATOR · University of Chicago

Who to contact

Angelica Perez-Gutierrez, MD
[email protected]
773-834-5087
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Eligibility criteria

Inclusion

Healthy subjects
Surgery residents in a 24-hour shift rotation
Gender of subjects: Males and females
Age of subjects: 18 years old and older
Racial and Ethnic Origin: Any race or ethnicity

Exclusion

Unwilling/unable to sign informed consent
Vulnerable Subjects/Subject Capacity to provide consent

What this trial measures

  • Characterization of the phenotype and function of immune cells using flow cytometry24 hours

    Specifically, T cells, B cells, dendritic cells, macrophages, and natural killer cells will be identified and analyzed. Memory cells, co-inhibitor markers, and regulatory markers will also be evaluated. The function will be analyzed based on the intracellular expression of effector molecules and cytokines after unspecific activation with CD3-CD28 beads.