NCT06636669
Probiotics in the Prevention of Recurrent Prosthetic Joint Infection of the Hip and Knee
Enrolling by Invitation
PHASE4Ages 18–90InterventionalTreatmentBoston Medical CenterInvestigator-initiated
~152 participants
Updated 2025-08-29 on ClinicalTrials.gov
What's tested:ProbioticStandard of care
At a glance
Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Recurrent Prosthetic Joint Infection (PJI)
Measured over 1 year, 2 years after PJI surgery
+1 more outcome measured
Conditions
Where it's being run
2 sites across 2 statesMassachusetts1
New York1
Study leadership
- Ayesha Abdeen, MD · PRINCIPAL_INVESTIGATOR · Boston Medical Center
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Diagnosis of PJI based upon Musculoskeletal Infection Society (MSIS) criteria
Planned treatment with surgical debridement, antibiotics, implant retention (DAIR), single- and two-stage revision TJA for PJI with an anticipated plan for eventual discontinuation of oral/IV antibiotics.
Patients with prior PJI in the same joint that has recurred.
Patients who understand the benefits and risks associated with taking a probiotic and are willing and able to provide informed consent.
Exclusion
Fungal PJI.
Inflammatory bowel disease, diverticulitis, history of intestinal surgery, or gastrointestinal
issue where there is concern for gut integrity.
History of pancreatitis at any point in time.
History of intolerance to probiotics.
Immunocompromised patients.
Revision TJA for aseptic reasons
What this trial measures
- Recurrent Prosthetic Joint Infection (PJI)1 year, 2 years after PJI surgery
The number of participants who develop PJI after PJI surgery will be abstracted from electronic medical records.
- Surgical Site Infection (SSI)3 months, 6 months, 12 months post PJI surgery
The number of participants who develop SSI within 12 months of PJI surgery will be abstracted from electronic medical records.