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Understanding Cancer Therapy Side Effects Using Stem Cells

This observational study aims to understand why some people experience side effects from cancer treatments like chemotherapy, targeted therapies, and immunotherapies. Researchers will collect a blood sample from you to create special cells called induced pluripotent stem cells (iPSCs). These iPSCs can then be turned into different cell types, like heart or nerve cells, to study how cancer treatments affect them. The goal is to learn more about how these side effects happen, if your genes play a role, and to potentially find new ways to protect against them. This study is for adults aged 18 and older who have received, are receiving, or will receive cancer therapy. The study plans to enroll 30 participants.

Study design
This is an observational study with a planned enrollment of 30 participants. It is not a treatment study.
What's involved
You would provide a blood sample and allow researchers to review your medical records.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06640010

Using Induced-Pluripotent Stem Cells to Model Cancer Therapy-Related Adverse Events

Recruiting
Not specifiedAges 18+Observational
Mayo Clinic
~30 participants
Updated 2026-06-23 on ClinicalTrials.gov
What's tested:Non-Interventional Study

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
In vitro measurement of cellular viability in response to chemotherapy
Measured over Blood drawn at enrollment to obtain sample

Conditions

Hematopoietic and Lymphatic System Neoplasm
Malignant Solid Neoplasm

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NCT06640010

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Mayo Clinic in Florida

    Jacksonville, Floridastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Nadine Norton, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Clinical Trials Referral Office
[email protected]
855-776-0015
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Any patient \>= 18 years of age
Previously treated, planned or currently receiving any potentially toxic cancer therapy including but not limited to chemotherapy, targeted and immunotherapies

Exclusion

Inability on the part of the patient to understand the informed consent or be compliant with the protocol

What this trial measures

  • In vitro measurement of cellular viability in response to chemotherapyBlood drawn at enrollment to obtain sample

    Will be compared between cells derived from patients who experienced treatment-induced toxicity to cells derived from patients who received the same cancer therapy without toxicity. Statistical analyses of different endpoints will use Fisher's exact test, one-way ANOVA test followed by all-pairwise-multiple-comparison procedures, or an unpaired, two-tailed Student's t-test with significant differences defined by P \< 0.05.