CHAAMP Pilot Study for Early Multiple Myeloma Detection

This study, called CHAAMP, is looking for people at higher risk for a blood cancer called multiple myeloma. The goal is to find multiple myeloma early, when it's still in a pre-cancerous stage called MGUS (Monoclonal Gammopathy of Undetermined Significance). By finding it early, doctors hope to prevent delays in diagnosis, reduce health problems from the cancer, and improve long-term health. You might be able to join if you are 30 or older and identify as Black and/or African American, OR if you have a close relative (parent, sibling, or child) with a plasma cell disorder like MGUS or multiple myeloma. The study involves a blood draw to check for MGUS. The main goal is to see how many people enroll in the study over one year. This is a pilot study, meaning it's testing the study methods before a larger effort begins.

Study design
This is an observational study, meaning researchers will observe participants without giving them a specific treatment. The study plans to enroll 1665 participants.
What's involved
You would have a screening blood sample collected. If you screen positive for monoclonal gammopathy, you would be referred to a clinic for further evaluation. If diagnosed with MGUS or smoldering multiple myeloma, you would be followed for 10 years.
Compensation
Not stated in the trial record.
Follow-up
Participants diagnosed with MGUS and smoldering multiple myeloma will be followed for 10 years. Participants with other plasma cell disorders will be followed for overall survival only.

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NCT06644625

CHAAMP (CHArlotte Advocate MGUS Project) Internal Pilot Study

Recruiting
Not specifiedAges 30+Observational
Wake Forest University Health Sciences
~1,665 participants
Updated 2026-07-13 on ClinicalTrials.gov
What's tested:Blood draw for the laboratory assessment

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of Participants who were Enrolled
Measured over Baseline, for an accrual period of one year
Multiple Myeloma
Multiple Myeloma Progression
Monoclonal Gammopathy of Undetermined Significance (MGUS)
Smoldering Multiple Myeloma (SMM)
Plasma Cell Disorders
1 sites across 1 states
North Carolina1
  • Manisha Bhutani, MD · PRINCIPAL_INVESTIGATOR · Atrium Health Wake Forest Baptist Comprehensive Cancer Center

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Eligibility criteria

Inclusion

Age 30 years or older at the time of consent
Either:
Capable and willing to provide informed consent. NOTE: HIPAA (Health Insurance Portability and Accountability Act) authorization for the release of personal health information may be included in the informed consent or obtained separately
Reside in Charlotte, NC, or the surrounding area, based on self-report
Test positive for monoclonal gammopathy during screening portion of the study
Consent to the longitudinal portion of the study

Exclusion

Self-reported history of MGUS, SMM, MM, AL amyloidosis, plasma cell leukemia, solitary plasmacytoma, Waldenstrom Macroglobulinemia, and POEMS.
The participant previously underwent diagnostic work up as part of CHAAMP Internal Pilot that did not result in a diagnosis of MGUS, Smoldering Multiple Myeloma or other non-plasma cell disorder.
  • Number of Participants who were EnrolledBaseline, for an accrual period of one year

    Determined for each potential participant approached to participate in this study (pre-screened), indicating whether or not the participant was enrolled (underwent blood draw to test for monoclonal gammopathy).