Observational Study of SVC-CI During CABG Surgery

This study is looking at how a measurement called the superior vena cava collapsibility index (SVC-CI) can help doctors understand if a patient needs more fluids during coronary artery bypass grafting (CABG) surgery. This surgery helps improve blood flow to your heart. Researchers will observe how your body responds to a temporary change in operating room table position, which mimics giving you extra fluids. They will measure your heart's output before and after this change. The goal is to find a specific SVC-CI value that helps doctors decide who will benefit from more fluids. You may be eligible if you are at least 18 years old, having CABG surgery, and can consent for yourself. This is an observational study, meaning researchers will watch and collect information without giving you a new treatment.

Study design
This is an observational study involving 120 participants undergoing CABG surgery. It is not specified if it is randomized or blinded.
What's involved
You will have cardiac output measurements taken at two times during your surgery. Your operating room table position will be changed for 60-90 seconds, adding about 10 minutes to your surgery time.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

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NCT06645327

SSVC-CI During CABG

Recruiting
Not specifiedAges 18+Observational
Milton S. Hershey Medical Center
~120 participants
Updated 2026-05-07 on ClinicalTrials.gov
What's tested:a change in operating room table position, which will mimic an IV fluid bolus

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To determine an appropriate cut-off value for the SVC-CI in participants with CAD undergoing isolated CABG to distinguish volume responders from non-responders.
Measured over 10 minutes of time added to your surgery time.
Coronary Artery Bypass Grafting Surgery (CABG)
1 sites across 1 states
Pennsylvania1
  • Edward Stredny, MD · PRINCIPAL_INVESTIGATOR · Milton S. Hershey Medical Center

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  • To determine an appropriate cut-off value for the SVC-CI in participants with CAD undergoing isolated CABG to distinguish volume responders from non-responders.10 minutes of time added to your surgery time.

    1. Responders increases by 12% or more following intervention 2. Non responders less than 12% change in CO following intervention.