Targeting Aging With a Ketone Ester for Function in Frailty
This study is looking at whether a dietary supplement called Ketone ester (KE) can help improve strength and overall well-being in adults aged 65 and older who are experiencing some decline in their physical function. Participants will be randomly assigned to receive either Ketone ester or a placebo (non-ketogenic canola oil) daily for 20 weeks. The main goal is to see if Ketone ester can improve a person's overall frailty score. To join, you must be at least 65 years old, pass a walking speed test, and weigh at least 50 kg. The study is currently unclear about its recruitment status and plans to enroll 180 people.
- Study design
- This is an interventional study with 180 planned participants. Participants will be randomly assigned to receive either Ketone ester or a placebo.
- What's involved
- You will have a screening visit and 4 additional study visits over 20 weeks. You will take a supplement daily at home and provide blood samples at all study visits.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your frailty composite score will be measured at baseline, 12 weeks, and 20 weeks.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Targeting Aging With a Ketone Ester for Function in Frailty
At a glance
Conditions
NCT06645847
Where you'd take part
This study runs at 3 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Buck Institute for Research on Aging
Novato, Californiastudy coordinator listed
Recruiting
Ohio State University
Columbus, Ohiostudy coordinator listed
Recruiting
UConn Health
Farmington, Connecticutstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- John Newman, MD, PhD · PRINCIPAL_INVESTIGATOR · Buck Institute
- Jeff Volek, Phd · PRINCIPAL_INVESTIGATOR · Ohio State University
- Jenna Bartley, PhD · PRINCIPAL_INVESTIGATOR · University of Connecticut
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Frailty composite scoreBaseline, 12 weeks, 20 weeks
The primary outcome measure is the difference in the change in a four-item composite score of vigor-frailty (6 minute walk, 1 rep max leg press, digit symbol substitution, Pittsburg Fatigability Scale - Physical sub scale) over 20 weeks between groups. The original composite score was developed by the Study of Muscle Mass and Aging Group, it is continuous, and a higher score corresponds to better function.