Acceptance and Commitment Therapy for HIV+ Hazardous Drinkers

This study is testing two approaches to help people living with HIV who drink alcohol at unhealthy levels. One approach is called Acceptance and Commitment Therapy (ACT), which uses mindfulness and values-based actions to help with mental and behavioral health challenges. The other is a Brief Alcohol Intervention (BI), a standard method to reduce drinking. Researchers want to see if these interventions can help reduce how often and how much you drink. You may be able to join if you are 18 or older, living with HIV, on HIV treatment, and drink at unhealthy levels. The study aims to enroll 300 participants.

Study design
This is an interventional study with a planned enrollment of 300 participants. It compares two behavioral interventions: Acceptance and Commitment Therapy (ACT) and a Brief Alcohol Intervention (BI).
What's involved
Your alcohol use will be measured at the start, 8 weeks later, and then at 3, 6, and 12 months after the start of the study.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 12 months after the start of the study to measure alcohol use.

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NCT06648629

Acceptance and Commitment Therapy for HIV+ Hazardous Drinkers

Recruiting
NAAges 18+InterventionalTreatment
Syracuse University
~300 participants
Updated 2026-02-04 on ClinicalTrials.gov
What's tested:Acceptance and Commitment Therapy (ACT)Brief Alcohol Intervention

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Alcohol use - Frequency
Measured over Measured at baseline, 8 weeks post-baseline, 3-, 6- , 12-months post-baseline
+2 more outcomes measured
HIV-1-infection
Alcohol Drinking
1 sites across 1 states
New York1

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Eligibility criteria

Inclusion

Living with HIV
Drink at unhealthy levels based on self-reported answers to the AUDIT-C, referencing drinking over the previous 3 months \[score of ≥4 (men) or ≥3 (women) will be used to identify eligible participants\]
on HIV treatment and are
18 years or older.
Read at an 8th grade level
Can provide a physical address
Able to provide informed consent

Exclusion

Anyone with a score = 12 on the AUDIT-C will be excluded.
Anyone with a score ≥20 on the PHQ-9, indicative of severe depression, will be excluded.
Anyone with a score of ≥15 on the GAD-7, indicative of severe anxiety, will be excluded.
  • Alcohol use - FrequencyMeasured at baseline, 8 weeks post-baseline, 3-, 6- , 12-months post-baseline

    The Timeline Followback will be used to estimate the Number of Drinking Days 30 days prior to study visit appointment

  • Alcohol Use - QuantityMeasured at baseline, 8 weeks post-baseline, 3-, 6- , 12-months post-baseline

    The Timeline Followback will be used to estimate the Number of Drinks per Drinking Day 30 days prior to study visit appointment

  • Phosphatidylethanol (PEth)Measured at baseline, 8 weeks post-baseline, 3-, 6- , 12-months post-baseline

    PEth is a metabolite, formed only in the presence of alcohol use and detectable in dried blood spots for approximately 3-4 weeks. The investigators will use both absolute PEth values and a cutoff of 50 mg/ml to indicate recent unhealthy alcohol use. Based on the consideration of both prevalence of underreport in the sample, the investigators will also consider using a compound measure of PEth+ (PEth ≥50ng/ml) and/or self-reported Alcohol Quantity \& Frequency via the AUDIT-C+ (≥4, men; ≥3, women) for any unhealthy alcohol use in the last 21 days as an outcome of interest.