IR-TMS for Alcohol Use Disorder

This study is testing a new treatment called Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for people with Alcohol Use Disorder (AUD). IR-TMS uses magnetic fields to target specific parts of the brain. You might be able to join if you are 18-65 years old, have a diagnosis of moderate to severe AUD, and meet certain drinking criteria, including a specific blood test result (PEth >20 ng/mL). The study aims to see if IR-TMS can help reduce the amount you drink. Success will be measured by changes in your PEth level at 1 and 6 months after starting the study. The study plans to enroll 150 participants.

Study design
This interventional study plans to enroll 150 participants with Alcohol Use Disorder. Participants will be randomly assigned to one of three treatment groups, each targeting a different brain area.
What's involved
You would receive up to 4 IR-TMS treatments per day for up to 10 days, have brain scans (MRI), provide blood and urine samples, and answer questions about your drinking and mental health.
Compensation
Not stated in the trial record.
Follow-up
Your PEth level will be measured at 1 month and 6 months after the start of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06648642

Image-guided, Robot Navigated Transcranial Magnetic Stimulation (IR-TMS) for Alcohol Use Disorder (AUD)

Recruiting
NAAges 18–65InterventionalTreatment
The University of Texas Health Science Center at San Antonio
~150 participants
Updated 2026-02-05 on ClinicalTrials.gov
What's tested:Transcranial Magnetic Stimulation (TMS)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Measure of Phosphatidylethanol (PEth) level
Measured over Baseline, 1 month and 6 months
Alcohol Use Disorder
1 sites across 1 states
Texas1
  • Brett C Ginsburg, PhD · PRINCIPAL_INVESTIGATOR · The University of Texas Health Science Center at San Antonio

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  • Measure of Phosphatidylethanol (PEth) levelBaseline, 1 month and 6 months

    Determine if accelerated IR-TMS significantly changes alcohol consumption (as measured by phosphatidylethanol (PEth)) in participants with AUD.