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NCT06649084

Primary Progressive Aphasia Multicomponent Language Treatment Study

Enrolling by Invitation
NAAll AgesInterventionalTreatment
University of Texas at Austin
~21 participants
Updated 2025-10-08 on ClinicalTrials.gov
What's tested:Multicomponent Lexical Retrieval Training (Multi-LRT)Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA)Multicomponent Communication Partner Training (Multi-CPT)

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in script production accuracy
Measured over change from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment
+3 more outcomes measured

Conditions

Primary Progressive Aphasia
Semantic Dementia
Semantic Memory Disorder
Logopenic Progressive Aphasia
Nonfluent Aphasia, Progressive
Aphasia
Aphasia, Progressive

Explore related trials

Logopenic progressive aphasiaPrimary Progressive AphasiaPrimary Progressive Nonfluent AphasiaSemantic dementia

Where it's being run

1 sites across 1 states
Texas1

Study leadership

  • Maya L Henry, PhD · PRINCIPAL_INVESTIGATOR · University of Texas at Austin

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Meets diagnostic criteria for Primary Progressive Aphasia (PPA; Gorno-Tempini et al., 2011)
Scores of 10 or higher on the Mini-Mental State Examination
Has a study partner who can consistently attend sessions

Exclusion

Other neurological or psychiatric diagnosis that may contribute to cognitive-linguistic deficits
Significant, uncorrected visual or hearing impairment that would interfere with participation
Score of less than 10 on the Mini-Mental State Examination
Prominent initial non-speech-language impairment (cognitive, behavioral, motoric)

What this trial measures

  • Change in script production accuracychange from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment

    Percent correct intelligible, scripted words for trained/untrained scripts

  • Change in spoken naming of trained/untrained itemschange from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment

    Percent correctly named trained/untrained pictures

  • Information communicated in any modality for trained/untrained stimulichange from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment

    Percent of major content units (key words) communicated via speech or nonspeech modalities (e.g., writing, drawing, gesture) for trained/untrained scripts (Multi-VISTA) or words (Multi-LRT) during structured probes and in conversation

  • Goal Attainment Scorechange from pre-treatment to post-treatment (approximately 6-12 weeks after treatment onset) and follow-ups at 3 months post-treatment

    The Goal Attainment Score is self-reported progress on personalized goals based on a five point scale.