Aquablation Therapy vs. Radical Prostatectomy for Localized Prostate Cancer

This study is comparing two treatments for localized prostate cancer: Aquablation Therapy and radical prostatectomy. Aquablation Therapy uses a robotic system with a high-velocity waterjet to remove prostate tissue. Radical prostatectomy is surgery to remove the entire prostate gland. You might be able to join if you are a man at least 45 years old with certain types of prostate cancer (Grade Group 1-3) that hasn't spread too far, and you are a candidate for or have chosen prostatectomy. The study will look at how well each treatment prevents urinary incontinence (leaking urine) and erectile dysfunction (problems with erections) after 6 months. The study aims to enroll 280 participants.

Study design
This is a randomized clinical trial, meaning participants will be randomly assigned to receive either Aquablation Therapy or radical prostatectomy. It is a multicenter study, involving several different locations.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 10 years after their treatment.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06651632

WATER IV Prostate Cancer

Active, Not Recruiting
NAAges 45+InterventionalTreatment
PROCEPT BioRobotics
~280 participants
Updated 2026-05-04 on ClinicalTrials.gov
What's tested:Aquablation TherapyRadical Prostatectomy

At a glance

Recruiting sites
0 of 37 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Rate of pad use for urinary incontinence
Measured over 6 Months
+1 more outcome measured
Localized Prostate Cancer
37 sites across 26 states
Florida4
United Kingdom3
Arizona2
Illinois2
Nebraska2
New York2
South Carolina2
Texas2

This trial hasn't published a contact. View it on ClinicalTrials.gov

  • Rate of pad use for urinary incontinence6 Months
  • Rate of erectile dysfunction6 Months