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Study on Glycerol and Electrolyte Beverages for Fluid Balance

This study is looking at how different electrolyte drinks, some with added glycerol, affect your body's fluid balance. Researchers want to see if these drinks help you retain fluids better than a plain placebo drink. They are testing several variations: a 0% carbohydrate electrolyte solution with or without glycerol, and 1% and 6% carbohydrate electrolyte solutions, all with glycerol. You might be able to join if you are a healthy man or woman between 18 and 50 years old, are recreationally active, and do not smoke. The study will measure changes in your body weight to see how well you retain fluids after drinking these beverages. The goal is to find out if adding glycerol helps maintain fluid balance.

Study design
This is an interventional study planning to enroll 95 healthy men and women. Participants will receive different beverage interventions, including placebo and various electrolyte solutions with or without glycerol.
What's involved
You will drink 28 ounces of a test beverage over 35 minutes, followed by a 25-minute rest. Your fluid balance will be measured at several time points up to 150 minutes after the last drink. Dosing days are separated by 2-15 days.
Compensation
Not stated in the trial record.
Follow-up
Your fluid balance will be monitored for 150 minutes after you finish drinking the test beverages on each study day.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06654557

Effect of Adding Glycerol to Electrolyte Beverages on Fluid Balance in Healthy Euhydrated Men and Women at Rest

Recruiting
NAAges 18–50InterventionalBasic science
PepsiCo Global R&D
~95 participants
Updated 2025-02-11 on ClinicalTrials.gov
What's tested:Placebo beverage, kiwi-strawberry flavor (Part 1 and Part 2)0% carbohydrate electrolyte solution with glycerol beverage (Part 1 only)0% carbohydrate electrolyte solution without glycerol beverage (Part 1 only)1% carbohydrate electrolyte solution with glycerol beverage (Parts 1 and 2)6% carbohydrate electrolyte solution with glycerol beverage (Parts 1 and 2)6% carbohydrate electrolyte solution without glycerol beverage (Part 2 only)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Fluid balance (Body Weight)
Measured over Change each test day from pre-beverage baseline (-60 minutes) to post-beverage Time 0 minutes, 30 minutes, 60 minutes, 90 minutes,120 minutes, and 150 minutes post 3rd (last) beverage
+1 more outcome measured

Conditions

Fluid Balance

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Lindsay Baker, PhD · PRINCIPAL_INVESTIGATOR · PepsiCo R&D Life Sciences, Sports Science

Who to contact

Lindsay Baker, PhD
[email protected]
814-883-9454
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

If female, subject is not pregnant (based on self-report)
Subject is 18-50 years of age, inclusive Subject is at least recreationally active (engaged in light to moderate intensity, intermittent, or steady-state exercise at least 3 days per week for at least 30 min at a time)
Subject does not smoke (or has quit for at least 6 months)
Subject is not taking medication that may interfere with the study (e.g., diuretics)
Subject has no health conditions that would interfere with the study, As indicated on the general health questionnaire (GHQ), e.g. cardiovascular, renal, or metabolic diseases
Subject is not allergic to adhesives (e.g., medical tape)
Subject is not allergic to kiwi-strawberry flavoring
Subject is willing to avoid alcohol consumption 24 hours prior to visit(s)
Subject is willing to fast overnight (\~8-12 hours)
Subject is willing to refrain from vigorous exercise for 24 hours (light physical activity only)
Subject is willing to eat the exact same food the day prior to each visit to the laboratory
Able to speak, write, and read English
Provision of written consent to participate

Exclusion

Subject has participated in a clinical trial within the past 30 days
Subject has participated in any PepsiCo trial within past 6 months
Subject has a condition or is taking medication that the investigator believes would interfere with his/her ability to provide informed consent, comply with the study protocol, which might confound the interpretation of the study results, or put the person at undue risk
Subject is employed by, or has a parent, guardian, or other immediate family member employed by a company that manufactures any products that compete with any Gatorade product. If subject is unsure if a company would be considered a competitor to Gatorade, they will be asked to please let the study investigator know the name of the other company and the nature of their relationship to that company before they sign the informed consent.

What this trial measures

  • Fluid balance (Body Weight)Change each test day from pre-beverage baseline (-60 minutes) to post-beverage Time 0 minutes, 30 minutes, 60 minutes, 90 minutes,120 minutes, and 150 minutes post 3rd (last) beverage

    Platform scale to the nearest 0.005 kilograms (kg)

  • Fluid balance (Percent (%) change in Body Mass)Change each test day from pre-beverage baseline (-60 minutes) to post-beverage Time 0 minutes, 30 minutes, 60 minutes, 90 minutes,120 minutes, and 150 minutes post 3rd (last) beverage

    Platform scale to the nearest 0.005 kilograms (kg)