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Contrast-enhanced Ultrasound for Acute Spinal Cord Injury

This study is looking at how a special ultrasound, called contrast-enhanced ultrasound (CEUS), can help doctors during surgery for acute spinal cord injury. During your surgery, a drug called Perflutren lipid will be injected. This allows doctors to see blood flow in your spinal cord using ultrasound. The goal is to see if this information can help doctors improve blood flow to the injured spinal cord, which might lead to better recovery. To join, you must be at least 18 years old, have had a spinal cord injury within the last 24 hours, and be stable enough for surgery. The study will measure how well patients recover over two years. The current status of this study is unclear.

Study design
This interventional study plans to enroll 50 participants. It is not specified if the study is randomized or blinded.
What's involved
You would undergo a bolus injection of Perflutren lipid and have ultrasound imaging during your routine spinal decompression surgery. This procedure does not prolong surgery time or increase its invasiveness.
Compensation
Not stated in the trial record.
Follow-up
Your outcomes will be checked for two years after the procedure.

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NCT06654804

Contrast-enhanced Ultrasound in the Treatment of Acute Spinal Cord Injury

Recruiting
PHASE4Ages 18+InterventionalTreatment
University of Washington
~50 participants
Updated 2025-04-27 on ClinicalTrials.gov
What's tested:Perflutren lipid

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Outcomes of all subjects who received contrast enhanced ultrasound imaging, to check perfusion during the surgical repair of an acute spinal cord injury.
Measured over Two years

Conditions

Acute Spinal Cord Injury

Explore related trials

Spinal Cord Injury

Where it's being run

1 sites across 1 states
Washington1

Study leadership

  • Christoph Hofstetter, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Washington

Who to contact

Amy Anderson
[email protected]
206-744-9364
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18 years of age minimum
Acute spinal cord injury fpr less than 24 hours
Injury ranging from mild spinal cord injury where motor function is preserved (AIS A) to complete injury where there is no motor or sensory function below the leel of the injury (AIS D)
Medically stable to undergo routine dorsal decompression, spinal realignment
and stabilizing with segmental instrumentation

Exclusion

Younger than 18 years old
Neurological lower extremity exam missing or intact
Traumatic head injury with a Glasgow score of 11 or lower
Cord injury level caudal to T10 (thoracic spine level 10)
A known sensitivity to lipid microsphere or its components, such as polyethylene glycol (PEG)
A history of anaphylactoid reactions from ultrasound enhancing agents
A known history of cardiopulmonary conditions
Cardiac shunt

What this trial measures

  • Outcomes of all subjects who received contrast enhanced ultrasound imaging, to check perfusion during the surgical repair of an acute spinal cord injury.Two years

    Knowledge of spinal cord hypoperfusion will allow the physician to optimize the hemodynamic condition of acute spinal cord injury and potentially improve outcomes. The investigators plan to use contrast-enhanced ultrasound to determine decreased blood flow in the spinal cord at the site of injury, during the routine surgery that these patients require to decompress and stabilize their injured spine.