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WePrEP: Improving PrEP Discussions for Transgender Women

This study is testing a new tool called WePrEP to help transgender women and their healthcare providers have better conversations about HIV prevention (PrEP). PrEP is medicine that can greatly reduce the chance of getting HIV. The study aims to see if WePrEP is easy to use and helpful compared to the usual way of discussing PrEP, which is based on CDC recommendations. WePrEP is designed to be used on a provider's electronic device and will be available in English and Spanish. You may be able to join if you are a transgender woman, 18-65 years old, live in the Denver area, speak English or Spanish, and are HIV-negative. The study is looking to enroll about 75 participants.

Study design
This study is comparing a new shared decision-making tool called WePrEP against standard CDC recommendations for discussing PrEP. It plans to enroll about 75 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Feasibility and acceptability will be measured at enrollment, but no further follow-up is specified.

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NCT06656676

WePrEP: Developing a PrEP Shared Decision-making Tool for Transgender Women

Recruiting
NAAges 18–65InterventionalPrevention
University of Colorado, Denver
~75 participants
Updated 2025-02-27 on ClinicalTrials.gov
What's tested:WePrEP: A shared decision-making toolActive comparator: CDC recommendations for discussing PrEP

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility
Measured over At enrollment
+1 more outcome measured

Conditions

HIV Prevention

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Stroke prevention

Where it's being run

1 sites across 1 states
Colorado1

Who to contact

Christine T Rael, PhD
[email protected]
303-734-8541
Email the study team

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Eligibility criteria

Inclusion

Self-identify as a transgender woman (e.g., was assigned male at birth, but currently reports a feminine gender identity)
Be between the ages of 18 and 65
Currently live in the Denver area
Speak English or Spanish
Be HIV-negative (via Alere Determine)
Not have participated in the development of WePrEP
Not currently take PrEP, but report they are "interested in doing more to protect themselves from HIV" \*\*We note that 1/3 of our RCT participants in the transgender women's group will be Black and/or Hispanic/Latina
Not have participated in the development of WePrEP
Live in the Denver area and (as a part of their employment responsibilities) discuss PrEP use with potential end-users.
Have helped at least 1 TW make a decision about PrEP (e.g., whether or not to use it, which specific PrEP modality, etc...) in the last month.
Do not live in the Denver area

Exclusion

Currently live with HIV

What this trial measures

  • FeasibilityAt enrollment

    Feasibility of Intervention Measure (FIM) \[Range: 1-5; Higher scores mean greater feasibility\]

  • AcceptabilityAt enrollment

    Acceptability of Intervention Measure (AIM) \[Range: 1-5; Higher scores mean greater acceptability\]