Normal-Weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide
This study is looking for women aged 30-70 with type 2 diabetes who are at a normal weight (BMI between 19 and 24.9 kg/m²). It aims to understand how fat cells (adipocytes) and fat distribution differ in normal-weight individuals with diabetes compared to those with diabetes who are overweight, and those without diabetes. Researchers will test if medications called pioglitazone or tirzepatide can improve how your body uses insulin (insulin resistance), how your fat cells work, and how fat is stored. Success would mean seeing improvements in insulin resistance, fat cell function, and fat storage. The study is currently unclear on its recruitment status and plans to enroll 104 participants.
- Study design
- This is an interventional study, meaning participants will receive specific treatments. It aims to enroll 104 participants, but the phase is not specified.
- What's involved
- You would undergo insulin resistance testing, an OGTT (oral glucose tolerance test) with 5 blood draws, a fat biopsy, a DXA scan, and an abdominal MRI.
- Compensation
- Not stated in the trial record.
- Follow-up
- Primary endpoints are measured at baseline comparisons between groups, so specific follow-up duration after treatment is not clear.
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Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide
At a glance
Conditions
Where it's being run
2 sites across 1 statesWho to contact
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What this trial measures
- Insulin resistance in normal weight women with diabetes compared to those with no diabetesBaseline measures comparison between the groups
Insulin resistance will be measured by a Steady State Plasma Glucose test (SSPG). Results will be measured by glucose levels at steady state in mg/dL.
- Adipocyte function in women with normal weight diabetes as compared with those without diabetesBaseline comparisons
Adipocyte function will be measured as percent small adipocytes and peak diameter adipocytes from the fat biopsies.
- Fat storage in women with normal weight diabetes compared to those without diabetesBaseline comparisons between the groups
Fat storage will be measured by MRI. Quantification of subcutaneous and visceral abdominal fat will be obtained by MRI using a fat-water imaging sequence (parameters: IDEAL-IQ: 3D GRE, 160x160 matrix, 6 echoes, 4 degree flip angle, minimum TR = 7.3 ms, 28 slices, 10 mm slice thickness.